Ekelund L G, Melcher A, Orö L
Eur J Clin Pharmacol. 1975 Jun 13;8(5):309-15. doi: 10.1007/BF00562655.
Exercise tolerance has been studied by two different methods, heart-rate-controlled exercise and stepwise increased load, in 12 patients with angina pectoris. The response to a beta-adrenergic blocking agent, alprenolol, and an alkyl nitrate derivative, pentaerythritol trinitrate (PETRIN) was studied by the two methods after double-blind administration of the drugs. Rating scales were used to quantitate the degree of dyspnoea, angina pectoris and tiredness in the legs. After PETRIN both methods showed significant increases in exercise tolerance (19 and 21 per cent). The heart-rate-controlled test showed a significant increase (33%) after alprenolol, but the change was not significant by the other method. In the patients studied, heart-rate-controlled exercise discriminated between active drug and placebo better than the stepwise increased load test, what might have been due to more optimal matching of the loads obtained in the heart-rate-controlled test. Indications are given about how to design an exercise study in patients with angina pectoris.
采用两种不同方法，即心率控制运动法和逐步增加负荷法，对12例心绞痛患者的运动耐力进行了研究。在双盲给药后，通过这两种方法研究了β-肾上腺素能阻滞剂阿普洛尔和硝酸酯衍生物季戊四醇三硝酸酯（PETRIN）的反应。使用评分量表对呼吸困难、心绞痛和腿部疲劳程度进行量化。服用PETRIN后，两种方法均显示运动耐力显著提高（分别提高19%和21%）。心率控制试验显示服用阿普洛尔后运动耐力显著提高（33%），但另一种方法显示的变化不显著。在所研究的患者中，心率控制运动法比逐步增加负荷试验能更好地区分活性药物和安慰剂，这可能是由于心率控制试验中获得的负荷匹配更优化。文中给出了有关如何设计心绞痛患者运动研究的建议。
