Pace Elisabetta, Cerveri Isa, Lacedonia Donato, Paone Gregorino, Sanduzzi Zamparelli Alessandro, Sorbo Rossella, Allegretti Marcello, Lanata Luigi, Scaglione Francesco
Institute of Translational Pharmacology (IFT), National Research Council, Via Ugo la Malfa, 153, 90146 Palermo, Italy.
Department of Internal Medicine and Medical Therapy, University of Pavia, 27100 Pavia, Italy.
Pharmaceutics. 2022 Jun 14;14(6):1261. doi: 10.3390/pharmaceutics14061261.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a versatile and complicated profile, being the fourth most common single cause of death worldwide. Several research groups have been trying to identify possible therapeutic approaches to treat COPD, such as the use of mucoactive drugs, which include carbocysteine. However, their role in the treatment of patients suffering from COPD remains controversial due to COPD's multifaceted profile. In the present review, 72 articles, published in peer-reviewed journals with high impact factors, are analyzed in order to provide significant insight and increase the knowledge about COPD considering the important contribution of carbocysteine in reducing exacerbations via multiple mechanisms. Carbocysteine is in fact able to modulate mucins and ciliary functions, and to counteract viral and bacterial infections as well as oxidative stress, offering cytoprotective effects. Furthermore, carbocysteine improves steroid responsiveness and exerts anti-inflammatory activity. This analysis demonstrates that the use of carbocysteine in COPD patients represents a well-tolerated treatment with a favorable safety profile, and might contribute to a better quality of life for patients suffering from this serious illness.
慢性阻塞性肺疾病（COPD）是一种具有多样且复杂特征的异质性疾病，是全球第四大常见的单一死因。多个研究团队一直在尝试确定治疗COPD的可能方法，比如使用黏液活性药物，其中包括羧甲司坦。然而，由于COPD的多方面特征，它们在治疗COPD患者中的作用仍存在争议。在本综述中，对发表在具有高影响因子的同行评审期刊上的72篇文章进行了分析，以便在考虑羧甲司坦通过多种机制减少病情加重的重要作用的情况下，提供有重要意义的见解并增加对COPD的了解。事实上，羧甲司坦能够调节黏蛋白和纤毛功能，对抗病毒和细菌感染以及氧化应激，具有细胞保护作用。此外，羧甲司坦可改善类固醇反应性并发挥抗炎活性。该分析表明，在COPD患者中使用羧甲司坦是一种耐受性良好、安全性良好的治疗方法，可能有助于改善患有这种严重疾病的患者的生活质量。
