Kállai-Szabó Nikolett, Lengyel Miléna, Farkas Dóra, Barna Ádám Tibor, Fleck Christian, Basa Bálint, Antal István
Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7-9, 1092 Budapest, Hungary.
Pharmaceutics. 2022 Jun 18;14(6):1299. doi: 10.3390/pharmaceutics14061299.
A significant proportion of pharmaceuticals are now considered multiparticulate systems. Modified-release drug delivery formulations can be designed with engineering precision, and patient-centric dosing can be accomplished relatively easily using multi-unit systems. In many cases, Multiple-Unit Pellet Systems (MUPS) are formulated on the basis of a neutral excipient core which may carry the layered drug surrounded also by functional coating. In the present summary, commonly used starter pellets are presented. The manuscript describes the main properties of the various nuclei related to their micro- and macrostructure. In the case of layered pellets formed based on different inert pellet cores, the drug release mechanism can be expected in detail. Finally, the authors would like to prove the industrial significance of inert cores by presenting some of the commercially available formulations.
现在，相当一部分药物被视为多颗粒系统。缓释药物递送制剂可以通过工程精度进行设计，并且使用多单元系统相对容易地实现以患者为中心的给药。在许多情况下，多单元微丸系统（MUPS）是基于中性辅料核心配制的，该核心可能承载着分层药物，周围也有功能性包衣。在本综述中，介绍了常用的起始微丸。该手稿描述了各种核与其微观和宏观结构相关的主要特性。对于基于不同惰性微丸核心形成的分层微丸，药物释放机制可以详细预测。最后，作者希望通过介绍一些市售制剂来证明惰性核心的工业意义。
