Zheng Bin, Yu Lulu, Dong Huaze, Zhu Jinmiao, Yang Liang, Yuan Xinsong
School of Chemistry and Chemical Engineering, Hefei Normal University, Hefei 230061, China.
Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China.
Polymers (Basel). 2022 Jun 14;14(12):2416. doi: 10.3390/polym14122416.
Endogenous gases have attracted much attention due to their potent applications in disease therapies. The combined therapy, including gaseous molecules and other medicines that can create synergistic effects, is a new way for future treatment. However, due to the gaseous state, gas utilization in medical service is still limited. To pave the way for future usage, in this work, an amphiphilic block copolymer containing nitrobenzyl ether, 3-hydroxyflavone (3-HF) derivatives and ether linker was constructed. The nitrobenzyl ether group endows the polymer with a photo-responsive character. Upon light illumination, 3-HF derivatives can be triggered for carbon monoxide (CO) release. The ether linker can also be released emitting formaldehyde (FA). The self-assembly induced micelle can encompass medicine, e.g., doxorubicin (DOX), into it and a controlled release of DOX can be realized upon light illumination. As far as we know, there is no report on the combination donor of CO and DOX and this is the first attempt on the co-release of CO, FA and DOX.
内源性气体因其在疾病治疗中的潜在应用而备受关注。包括气态分子和其他能产生协同效应的药物的联合治疗是未来治疗的一种新方式。然而，由于气体的状态，其在医疗服务中的利用仍然有限。为了为未来的应用铺平道路，在这项工作中，构建了一种含有硝基苄基醚、3-羟基黄酮（3-HF）衍生物和醚连接基的两亲性嵌段共聚物。硝基苄基醚基团赋予聚合物光响应特性。光照后，3-HF衍生物可被触发释放一氧化碳（CO）。醚连接基也可释放出甲醛（FA）。自组装诱导的胶束可以包封药物，如阿霉素（DOX），并且光照后可以实现DOX的控释。据我们所知，尚无关于CO和DOX联合供体的报道，这是首次尝试CO、FA和DOX的共释放。
