神经节苷脂单克隆抗体（A2B5）标记阿尔茨海默病神经原纤维缠结。
Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles.
作者信息
Emory C R, Ala T A, Frey W H
出版信息
Neurology. 1987 May;37(5):768-72. doi: 10.1212/wnl.37.5.768.
PMID:3574674
Abstract
Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles both in isolated neurofibrillary tangle-bearing nerve cells and in partially purified preparations of tangle fibers. Antibody staining was preabsorbed by preincubation of antibody with neuronal ganglioside preparations. These results suggest that Alzheimer's neurofibrillary tangles have a ganglioside associated with them.
摘要
神经节苷脂单克隆抗体（A2B5）可标记分离出的带有神经原纤维缠结的神经细胞以及部分纯化的缠结纤维制剂中的阿尔茨海默病神经原纤维缠结。抗体染色可通过抗体与神经元神经节苷脂制剂预孵育而被预先吸收。这些结果表明，阿尔茨海默病神经原纤维缠结与一种神经节苷脂相关联。
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