Department of Microbiology, Stellenbosch University, Stellenbosch 7600, South Africa.
Institute for Microbial Biotechnology and Metagenomics, University of the Western Cape, Bellville 7535, South Africa.
Viruses. 2022 Jun 15;14(6):1309. doi: 10.3390/v14061309.
is frequently associated with complicated urinary tract infections (UTIs) and is the main cause of catheter-associated urinary tract infections (CAUTIs). Treatment of such infections is complicated and challenging due to the biofilm forming abilities of . If neglected or mistreated, infections may lead to life-threating conditions such as cystitis, pyelonephritis, kidney failure, and bacteremia that may progress to urosepsis. Treatment with antibiotics, especially in cases of recurring and persistent infections, leads to the development of resistant strains. Recent insights into phage therapy and using phages to coat catheters have been evaluated with many studies showing promising results. Here, we describe a highly lytic bacteriophage, _virus_309 (41,740 bp), isolated from a wastewater treatment facility in Cape Town, South Africa. According to guidelines of the International Committee on Taxonomy of Viruses (ICTV), bacteriophage 309 is a species within the genus . Similar to most members of the genus, bacteriophage 309 is strain-specific and lyse in less than 20 min.
常与复杂尿路感染（UTI）相关，是导管相关性尿路感染（CAUTI）的主要原因。由于 的生物膜形成能力，此类感染的治疗变得复杂且具有挑战性。如果忽视或治疗不当，感染可能导致危及生命的情况，如膀胱炎、肾盂肾炎、肾衰竭和菌血症，这些情况可能进展为尿路感染性休克。抗生素治疗，尤其是在反复发作和持续性感染的情况下，会导致耐药菌株的产生。最近对噬菌体治疗的深入了解以及使用噬菌体涂覆导管的方法已经在许多研究中得到了评估，这些研究显示出了有前景的结果。在这里，我们描述了一种从南非开普敦的一家废水处理厂中分离出来的高度裂解噬菌体 _virus_309（41740bp）。根据病毒分类国际委员会（ICTV）的指南，噬菌体 309 是属内的一个种。与大多数属成员一样，噬菌体 309 是菌株特异性的，在不到 20 分钟内裂解 。
