成年智障精神科门诊患者的他汀类药物处方与心血管风险评估
Statin prescription and CV risk assessment in adult psychiatric outpatients with intellectual disability.
作者信息
Ho Jamie Sin Ying, Collins George, Rohra Vikram, Korb Laura, Perera Bhathika
机构信息
Foundation Doctor Haringey Learning Disability Partnership, Barnet, Enfield and Haringey Mental Health Trust, River Park House, Second Floor, 225 High Road, Wood Green, London, N22 8HQ.
Cardiology Registrar, Barts Health NHS Trust, and Wellcome Trust Clinical Research Fellow at University College London Department of Cardiology, Barts Health NHS Trust, West Smithfield, London, EC1A 7BE.
出版信息
Br J Cardiol. 2021 Nov 30;28(4):49. doi: 10.5837/bjc.2021.049. eCollection 2021.
We performed a single-centre study to assess the risk of cardiovascular disease (CVD) in psychiatry outpatients with intellectual disability (ID) using the QRISK-3 score. There were 143 patients known to the ID psychiatry clinic enrolled. Of these, 28 (19.6%) had elevated CVD risk - defined as 10-year risk of heart attack or stroke of ≥10%. Of these, 57.1% were not prescribed statin therapy, which - after lifestyle measures - is recommended by National Institute for Health and Care Excellence (NICE) guidelines. The mean QRISK-3 score was 6.31% (95% confidence interval [CI] 4.84 to 7.78), with a relative risk of 3.50 (95%CI 2.34 to 4.67) compared with matched controls. The high CVD risk identified in this study supports routine CVD risk assessment and management in adult outpatients with ID. Appropriate lifestyle measures and statin therapy could help reduce the excess CVD-related morbidity and mortality in ID patients.
我们开展了一项单中心研究，使用QRISK-3评分评估患有智力障碍（ID）的精神科门诊患者的心血管疾病（CVD）风险。共有143名已知在ID精神科诊所就诊的患者入组。其中，28名（19.6%）患者的CVD风险升高，即10年内心脏病发作或中风风险≥10%。其中，57.1%的患者未接受他汀类药物治疗，而英国国家卫生与临床优化研究所（NICE）指南建议，在采取生活方式措施后，应使用他汀类药物治疗。QRISK-3评分的平均值为6.31%（95%置信区间[CI]为4.84至7.78），与匹配的对照组相比，相对风险为3.50（95%CI为2.34至4.67）。本研究中确定的高CVD风险支持对成年ID门诊患者进行常规CVD风险评估和管理。适当的生活方式措施和他汀类药物治疗有助于降低ID患者中与CVD相关的额外发病率和死亡率。
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