Jamshidi-Adegani Fatemeh, Vakilian Saeid, Al-Kindi Juhaina, Rehman Najeeb Ur, Alkalbani Laila, Al-Broumi Mohammed, Al-Wahaibi Nasar, Shalaby Asem, Al-Sabahi Jamal, Al-Harrasi Ahmed, Al-Hashmi Sulaiman
Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, P. O. Box: 33, PC 616, Oman.
Natural Products Laboratory, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, P. O. Box: 33, PC 616, Oman.
J Tradit Complement Med. 2021 Oct 15;12(4):367-374. doi: 10.1016/j.jtcme.2021.10.004. eCollection 2022 Jul.
and purpose: The formation of postoperative intra-abdominal adhesion band formation may lead to severe complications. This study aimed to evaluate the preventive effect of local administration of frankincense n-hexane extract (FHE) on the formation of postsurgical adhesion bands.
FHE was extracted from the resin of a tree and its components were identified by gas chromatography-mass spectrometry (GC-MS). In an animal model, the expression levels of TNF-α and TGF-β1 cytokines after application of FHE were assessed to check the inflammatory and fibrotic cues, respectively.
Following FHE compound analysis, experiments demonstrated that intraoperative local administration of FHE resulted in the prevention of adhesion band formation. The adhesion grades in the FHE-treated group were significantly lower than those in the negative control (NC) and the positive control (Interceed). The infiltration of inflammatory cells observed by histopathology revealed a significant anti-inflammatory potential of FHE. Furthermore, the gene expression results proved that significant suppression of TNF-α and TGF-β1 was responsible for its antiadhesion properties.
The study reported the potential of FHE as an ointment for the prevention of adhesion bands.
术后腹腔内粘连带的形成可能导致严重并发症。本研究旨在评估局部应用乳香正己烷提取物（FHE）对术后粘连带形成的预防作用。
从一种树的树脂中提取FHE，并通过气相色谱 - 质谱联用（GC-MS）鉴定其成分。在动物模型中，评估应用FHE后TNF-α和TGF-β1细胞因子的表达水平，分别检查炎症和纤维化线索。
经过FHE成分分析，实验表明术中局部应用FHE可预防粘连带形成。FHE治疗组的粘连分级显著低于阴性对照组（NC）和阳性对照组（Interceed）。组织病理学观察到的炎性细胞浸润显示FHE具有显著的抗炎潜力。此外，基因表达结果证明，TNF-α和TGF-β1的显著抑制是其抗粘连特性的原因。
该研究报道了FHE作为预防粘连带软膏的潜力。
