School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Curr Org Synth. 2023;20(4):365-375. doi: 10.2174/1570179419666220624120250.
In this paper, a novel catalyst is synthesized and characterized by immobilizing copper onto imidazopyridine-modified superparamagnetic iron oxide nanoparticles (SPION).
The catalyst is characterized by several methods, including TEM, SEM, ICP, DLS, and VSM. The catalytic activity of the catalyst is evaluated in the synthesis of thiosolfunamide. The synthesized catalyst showed very good activity in the mentioned reaction and performance for synthesizing the desired products in high isolated yields.
For the synthesis of the products, sequential transformations enable the facile synthesis of complex target molecules from simple building blocks in a single preparative step.
The reaction can be performed with a high yield using water and ethanol as the reaction green solvent using terminal alkynes and sulfonyl azides as starting materials. The reusability of the catalyst was tested, and the results proved high reusability of the catalyst.
在本文中，通过将铜固定在咪唑吡啶修饰的超顺磁性氧化铁纳米粒子（SPION）上，合成并表征了一种新型催化剂。
该催化剂通过 TEM、SEM、ICP、DLS 和 VSM 等多种方法进行了表征。在硫代磺酰胺的合成中评价了催化剂的催化活性。所合成的催化剂在所述反应中表现出非常好的活性，并且能够以高分离收率合成所需产物。
对于产物的合成，通过连续转化，可以从简单的起始原料在单个制备步骤中轻松合成复杂的目标分子。
该反应可以以高产率进行，使用水和乙醇作为反应绿色溶剂，以末端炔烃和磺酰基叠氮化物作为起始原料。测试了催化剂的可重复使用性，结果证明催化剂具有很高的可重复使用性。
