Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Expert Rev Endocrinol Metab. 2022 Jul;17(4):319-331. doi: 10.1080/17446651.2022.2089112. Epub 2022 Jun 24.
Eating disorders (EDs) are common complications in people with type 1 diabetes (PwT1D), given the rigid focus on food and insulin dose adjustment. Dietary recommendations for T1D match those for the general population, yet many fail to achieve target HbA1c. Evidence suggests that lower carbohydrate meals and thus reduced insulin requirements may decrease inconsistencies in insulin absorption, maintain euglycemia and weight. Dietary restriction is a recognized risk factor for ED development, and Ketogenic Diets (KD) involve restriction of common family-based foods, thus impacting social normality and microbiome diversity. We reviewed the current literature on PwT1D following a KD to understand effects on ED risks.
Published data from MEDLINE, Embase, and PsycINFO were used. Search terms included: type 1 diabetes mellitus; or insulin dependent diabetes or T1D AND EDs or anorexia or bulimia or disordered eating AND low-carbohydrate diet or carbohydrate restricted diet or low carb diet or ketogenic diet.
Research into the effects of KDs on ED outcomes in PwT1D are limited, given the concerns over risks of diabetic ketoacidosis, hypoglycemia, and dyslipidemia. Longer term studies on the participants' experience and motivations of adhering or admonishing the diet are needed.
由于人们对食物的严格关注和胰岛素剂量的调整,饮食障碍(EDs)是 1 型糖尿病患者(PwT1D)的常见并发症。T1D 的饮食建议与一般人群的建议相匹配,但许多人未能达到目标 HbA1c。有证据表明,低碳水化合物餐和因此减少胰岛素需求可能会减少胰岛素吸收的不一致性,维持血糖正常和体重。饮食限制是 ED 发展的公认危险因素,而生酮饮食(KD)涉及限制常见的基于家庭的食物,从而影响社会常态和微生物组多样性。我们回顾了关于 PwT1D 遵循 KD 的现有文献,以了解其对 ED 风险的影响。
使用 MEDLINE、Embase 和 PsycINFO 上发表的数据。搜索词包括:1 型糖尿病;或胰岛素依赖型糖尿病或 T1D 和 EDs 或厌食症或贪食症或饮食障碍和低碳水化合物饮食或碳水化合物限制饮食或低碳饮食或生酮饮食。
由于对糖尿病酮症酸中毒、低血糖和血脂异常的风险的担忧,关于 KD 对 PwT1D 中 ED 结果的影响的研究是有限的。需要对参与者的经验和坚持或告诫饮食的动机进行更长期的研究。