通过可见光诱导的烯烃与α-氟代羧酸的氢单氟烷基化和二氟烷基化直接合成烷基氟化物。
Straightforward Synthesis of Alkyl Fluorides via Visible-Light-Induced Hydromono- and Difluoroalkylations of Alkenes with α-Fluoro Carboxylic Acids.
作者信息
Guo Chunfang, Han Xuliang, Feng Yu, Liu Zhaolong, Li Yueyun, Liu Hui, Zhang Lizhi, Dong Yunhui, Li Xinjin
机构信息
School of Chemistry and Chemical Engineering, Shandong University of Technology, 266 West Xincun Road, Zibo 255000, P. R. China.
Shandong Vocational College of Light Industry, Zhoucun Mishan Road, Zibo 255300, P. R. China.
出版信息
J Org Chem. 2022 Jul 15;87(14):9232-9241. doi: 10.1021/acs.joc.2c00965. Epub 2022 Jun 24.
We herein report the first visible-light-induced hydromono- and difluoroalkylations of alkenes with inexpensive and easily accessible α-fluoro carboxylic acids. This metal-free protocol exhibits mild conditions, high efficiency, and excellent functional-group tolerance, providing a straightforward approach to mono- and difluoroalkylated alkanes. Moreover, the fluorine effect on the hydrofluoroalkylation reaction is discussed in detail.
我们在此报告了首例可见光诱导的烯烃与廉价且易于获得的α-氟代羧酸的氢单氟烷基化和二氟烷基化反应。这种无金属的反应方案具有温和的条件、高效性和出色的官能团耐受性，为单氟烷基化和二氟烷基化烷烃提供了一种直接的方法。此外，还详细讨论了氟对氢氟烷基化反应的影响。
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