四取代丙二烯的合成：一个1,4-钯迁移/卡宾插入/β-氢消除序列。
Synthesis of tetrasubstituted allenes a 1,4-palladium migration/carbene insertion/β-H elimination sequence.
作者信息
Zhang Ge, Feng Xiao-Jiao, Li Meng-Yao, Ji Xiao-Ming, Lin Guo-Qiang, Feng Chen-Guo
机构信息
The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai, 200032, China.
出版信息
Org Biomol Chem. 2022 Jul 13;20(27):5383-5386. doi: 10.1039/d2ob00751g.
A palladium-catalyzed synthesis of tetrasubstituted allenes from aryl bromides and aryl diazoacetates is developed. This transformation proceeded an aryl to alkenyl 1,4-palladium migration/carbene insertion/β-H elimination sequence under mild reaction conditions.
开发了一种钯催化的由芳基溴化物和芳基重氮乙酸酯合成四取代丙二烯的方法。该转化过程在温和的反应条件下通过芳基到烯基的1,4-钯迁移/卡宾插入/β-H消除序列进行。
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