Ovicidal, pupicidal, adulticidal, and repellent activity of K. Schum against L. (Diptera: Culicidae).

is a vector of emerging and neglected diseases, such as dengue, chikungunya, and Zika. known as "pitó" in Brazil, is traditionally used as an insect repellent, and several studies have demonstrated its larvicidal activity. The aim of this study was to investigate this species and evaluate its potential ovicidal, pupicidal, adulticidal, and repellent activity. The viability of the eggs was evaluated using different concentrations of the test substances for 25 days. The hexane fraction killed 72.7% of the eggs, while dichloromethane killed 67.7%. The survival of the pupae and adults was verified after 72 h and 48 h, respectively. The LC for the hexane and dichloromethane fractions was 0.12 mg/mL and 8.85 mg/mL for pupae, 8.01 mg/mL and 0.74 mg/mL for adults (tarsal test), and 0.05 mg/mL and 0.23 mg/mL for adults (body test), respectively. Repellency was assessed for 240 min using neonatal Wistar rats on a Y-tube olfactometer. The hexane fraction attracted mosquitoes to the test chamber, while the dichloromethane fraction had a repellent action. The 7,4'-di--methyl-8--sulfate flavone provides greater repellency, and this finding is similar to the results of the studies that have shown the potential of this substance against adult mosquitoes. This suggests that 7,4'-di--methyl-8--sulfate flavone may be one of the substances present in the extract from aerial parts of that is responsible for the repellent activity mentioned in traditional medicine. These findings provide a better understanding of the insecticidal and repellent activity of the extract, fraction, and compounds isolated from against thereby revealing its potential in the development of a more effective botanical insecticide.