Department of Livestock Population Genomics, Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.
PLoS One. 2022 Jun 24;17(6):e0270550. doi: 10.1371/journal.pone.0270550. eCollection 2022.
Mitochondria and the energy metabolism are linked to both, the availability of Ca and P to provide the eukaryotic cell with energy. Both minerals are commonly used supplements in the feed of laying hens but little is known about the relationship between the feed content, energy metabolism and genetic background. In this study, we provide a large-scaled gene expression analysis of 31 mitochondrial and nuclear encoded genes in 80 laying hens in the context of dietary P and Ca concentrations. The setup included five tissues and gene expression was analysed under four different diets of recommended and reduced Ca and P concentrations. Our study shows, that mitochondrial gene expression is reacting to a reduction in P and that an imbalance of the nutrients has a higher impact than a combined reduction. The results suggest, that both strains (Lohmann Brown and Lohmann Selected Leghorn) react in a similar way to the changes and that a reduction of both nutrients might be possible without crucial influence on the animals' health or gene expression.
线粒体和能量代谢与钙（Ca）和磷（P）的可用性有关，这两种矿物质通常被用作产蛋鸡饲料的补充物，但人们对饲料含量、能量代谢和遗传背景之间的关系知之甚少。在这项研究中，我们在不同的钙（Ca）和磷（P）浓度饮食条件下，对 80 只产蛋鸡的 31 个线粒体和核编码基因进行了大规模的基因表达分析。该研究包括五个组织，在四种不同的饮食条件下分析了基因表达情况。我们的研究表明，线粒体基因表达对磷的减少有反应，而且营养物质的不平衡比两者的共同减少影响更大。结果表明，两个品系（罗曼褐和洛曼选莱杭）对这些变化的反应方式相似，在不影响动物健康或基因表达的情况下，减少这两种营养物质是可能的。
