细菌中的靶向蛋白降解：BacPROTACs 基础篇

BacPROTACs to basics: Targeted protein degradation in bacteria.

机构信息

Department of Biochemistry and Biophysics, Department of Cancer Biology and Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.

出版信息

Cell. 2022 Jun 23;185(13):2203-2205. doi: 10.1016/j.cell.2022.05.026.

DOI:10.1016/j.cell.2022.05.026

PMID:35750029

Abstract

Targeted protein degradation has emerged as a powerful tool for therapeutic development and biological exploration. In this issue of Cell, Morreale et al. report the development of the BacPROTAC technology to enable targeted protein degradation in Gram-positive bacteria and mycobacteria via reprogramming of Clp proteases.

摘要

靶向蛋白降解已成为治疗开发和生物探索的有力工具。在本期《细胞》杂志上，Morreale 等人报告了 BacPROTAC 技术的发展，该技术通过重新编程 Clp 蛋白酶，可实现革兰氏阳性菌和分枝杆菌中的靶向蛋白降解。