Pala Laura, De Pas Tommaso, Catania Chiara, Giaccone Giuseppe, Mantovani Alberto, Minucci Saverio, Viale Giuseppe, Gelber Richard D, Conforti Fabio
Division of Melanoma, Sarcomas and Rare Tumors, European Institute of Oncology, Milan, Italy.
Division of Thoracic Oncology, European Institute of Oncology, IRCCS, Milan, Italy.
Cancer Cell. 2022 Jul 11;40(7):695-700. doi: 10.1016/j.ccell.2022.06.005. Epub 2022 Jun 23.
Recent evidence highlights patients' sex relevance in antitumor immune response through a complex interaction-among hormones, genes, behaviors, and the microbiome-that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors.
最近的证据突显了患者性别在抗肿瘤免疫反应中的相关性，这是通过激素、基因、行为和微生物群之间的复杂相互作用实现的，这些相互作用会影响先天性和适应性免疫功能以及免疫逃逸机制。这些复杂的相互作用最终会影响实体瘤中免疫检查点抑制剂的疗效和毒性。
