化疗治疗晚期前列腺癌患者并发肺炎:病例报告。

pneumonia in a patient receiving chemotherapy for advanced prostatic cancer: a case report.

机构信息

Department of Pulmonary Medicine and Critical Medicine, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

出版信息

J Int Med Res. 2022 Jun;50(6):3000605221105358. doi: 10.1177/03000605221105358.

Abstract

pneumonia (PJP) in advanced prostatic cancer patients not receiving high-dose glucocorticoids has been reported rarely. A 73-year-old man underwent chemotherapy with cisplatin and docetaxel for advanced prostatic cancer. After nine cycles of chemotherapy, he developed a high fever, dry cough, shortness of breath, and severe fatigue, with rapid-onset hypoxic respiratory failure. Investigations demonstrated bilateral ground-glass opacities with positive bronchoalveolar lavage fluid (BALF) for by next-generation sequencings (NGS). The patient recovered well with treatment with trimethoprim-sulfamethoxazole, caspofungin, and corticosteroids. This case report describes a case of PJP in a patient with a solid tumor who did not receive high-dose glucocorticoids and emphasizes the importance of early diagnosis and treatment.

摘要

据报道,在未接受大剂量糖皮质激素治疗的晚期前列腺癌患者中,很少发生肺炎(PJP)。一位 73 岁男性因晚期前列腺癌接受顺铂和多西他赛化疗。化疗九周期后,他出现高热、干咳、呼吸急促和严重乏力,并迅速发生低氧性呼吸衰竭。检查显示双侧磨玻璃影,支气管肺泡灌洗液(BALF)经下一代测序(NGS)检测为阳性。患者经甲氧苄啶-磺胺甲噁唑、卡泊芬净和皮质类固醇治疗后恢复良好。本病例报告描述了一例未接受大剂量糖皮质激素治疗的实体瘤患者发生 PJP 的情况,并强调了早期诊断和治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c09/9237926/df7cfc2feacd/10.1177_03000605221105358-fig1.jpg

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