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Solid phase synthesis of peptides containing the CH2NH peptide bond isostere.

作者信息

Sasaki Y, Coy D H

出版信息

Peptides. 1987 Jan-Feb;8(1):119-21. doi: 10.1016/0196-9781(87)90174-4.

DOI:10.1016/0196-9781(87)90174-4
PMID:3575146
Abstract

The CH2NH peptide bond can be directly introduced by the reductive alkylation reaction between a tert-butoxycarbonyl-amino acid aldehyde and an amine on the resin bound peptide employing sodium cyanoborohydride in acidified dimethylformamide solution and this facile method was successfully applied to the synthesis of a psi[CH2NH] pseudopeptide somatostatin octapeptide analogue.

摘要

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