Malec D, Langwiński R
Pol J Pharmacol Pharm. 1986 Sep-Dec;38(5-6):501-7.
The effect of agonists and antagonists of the gabaergic system on catalepsy induced by morphine, fentanyl and haloperidol was investigated in the rat. The compounds inhibiting gabaergic neurotransmission, bicuculline and picrotoxin, given in subconvulsive doses (0.1-0.5 mg/kg) in general do not evidently affect cataleptogenic effects of the analgesics and haloperidol. Of the gabaergic agonists muscimol (0.2-0.5 mg/kg) potentiates only the haloperidol catalepsy, without changing the action of analgesics. Aminooxyacetic acid (AOAA, 25 mg/kg) markedly potentiated the catalepsy brought about by analgesics, while weakly and insignificantly facilitated that induced by haloperidol. Baclofen in a low dose (1 mg/kg) antagonized the action of haloperidol and fentanyl, whereas in higher doses (2-8 mg/kg) it did not visibly affect the action of any investigated drugs. Thus the action of gabaergic agonists and antagonists on the analgesic and haloperidol catalepsy varies, depending on the dose and kind of the agent affecting the gabaergic system.
在大鼠中研究了γ-氨基丁酸能系统的激动剂和拮抗剂对吗啡、芬太尼和氟哌啶醇所致僵住症的影响。抑制γ-氨基丁酸能神经传递的化合物荷包牡丹碱和印防己毒素，以亚惊厥剂量（0.1 - 0.5毫克/千克）给予时，一般不会明显影响镇痛药和氟哌啶醇的致僵住症作用。在γ-氨基丁酸能激动剂中，蝇蕈醇（0.2 - 0.5毫克/千克）仅增强氟哌啶醇所致的僵住症，而不改变镇痛药的作用。氨基氧乙酸（AOAA，25毫克/千克）显著增强镇痛药所致的僵住症，而对氟哌啶醇所致的僵住症仅有微弱且不显著的促进作用。低剂量（1毫克/千克）的巴氯芬拮抗氟哌啶醇和芬太尼的作用，而高剂量（2 - 8毫克/千克）时它对任何所研究药物的作用均无明显影响。因此，γ-氨基丁酸能激动剂和拮抗剂对镇痛药和氟哌啶醇所致僵住症的作用各不相同，这取决于影响γ-氨基丁酸能系统的药物剂量和种类。
