Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital/The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD, 21287, USA.
New York University Grossman School of Medicine, New York University, New York, NY, USA.
Eur Radiol. 2022 Dec;32(12):8670-8680. doi: 10.1007/s00330-022-08937-7. Epub 2022 Jun 25.
To test whether a 4-fold accelerated 3D T2-weighted (T2) CAIPIRINHA SPACE TSE sequence with isotropic voxel size is equivalent to conventional 2DT2 TSE for the evaluation of intrinsic and perilesional soft tissue tumors (STT) characteristics.
For 108 patients with histologically-proven STTs, MRI, including 3DT2 (CAIPIRINHA SPACE TSE) and 2DT2 (TSE) sequences, was performed. Two radiologists evaluated each sequence for quality (diagnostic, non-diagnostic), tumor characteristics (heterogeneity, signal intensity, margin), and the presence or absence of cortical involvement, marrow edema, and perilesional edema (PLE); tumor size and PLE extent were measured. Signal-to-noise (SNR) and contrast-to-noise (CNR) ratios and acquisition times for 2DT2 in two planes and 3DT2 sequences were reported. Descriptive statistics and inter-method agreement were reported.
Image quality was diagnostic for all sequences (100% [108/108]). No difference was observed between 3DT2 and 2DT2 tumor characteristics (p < 0.05). There was no difference in mean tumor size (3DT2: 2.9 ± 2.5 cm, 2DT2: 2.8 ± 2.6 cm, p = 0.4) or PLE extent (3DT2:0.5 ± 1.2 cm, 2DT2:0.5 ± 1.0 cm, p = 0.9) between the sequences. There was no difference in the SNR of tumors, marrow, and fat between the sequences, whereas the SNR of muscle was higher (p < 0.05) on 3DT2 than 2DT2. CNR measures on 3DT2 were similar to 2DT2 (p > 0.1). The average acquisition time was shorter for 3DT2 compared with 2DT2 (343 ± 127 s vs 475 ± 162 s, respectively).
Isotropic 3DT2 MRI offers higher spatial resolution, faster acquisition times, and equivalent assessments of STT characteristics compared to conventional 2DT2 MRI in two planes. 3DT2 is interchangeable with a 2DT2 sequence in tumor protocols.
• Isotropic 3DT2 CAIPIRINHA SPACE TSE offers higher spatial resolution than 2DT2 TSE and is equivalent to 2DT2 TSE for assessments of soft tissue tumor intrinsic and perilesional characteristics. • Multiplanar reformats of 3DT2 CAIPIRINHA SPACE TSE can substitute for 2DT2 TSE acquired in multiple planes, thereby reducing the acquisition time of MRI tumor protocols. • 3DT2 CAIPIRINHA SPACE TSE and 2DT2 TSE had similar CNR of tissues.
测试具有各向同性体素大小的 4 倍加速 3D T2 加权（T2）CAIPIRINHA SPACE TSE 序列是否等同于常规 2DT2 TSE，用于评估内在和肿瘤周围软组织肿瘤（STT）特征。
对 108 例经组织学证实的 STT 患者进行 MRI 检查，包括 3DT2（CAIPIRINHA SPACE TSE）和 2DT2（TSE）序列。两名放射科医生评估了每个序列的质量（诊断性、非诊断性）、肿瘤特征（异质性、信号强度、边界）以及皮质受累、骨髓水肿和肿瘤周围水肿（PLE）的存在或不存在；测量肿瘤大小和 PLE 范围。报告了 2 个平面的 2DT2 和 3DT2 序列的信噪比（SNR）和对比噪声比（CNR）比值和采集时间。报告了描述性统计数据和方法间一致性。
所有序列的图像质量均为诊断性（100%[108/108]）。3DT2 和 2DT2 肿瘤特征之间未见差异（p<0.05）。序列之间肿瘤大小（3DT2：2.9±2.5cm，2DT2：2.8±2.6cm，p=0.4）或 PLE 范围（3DT2：0.5±1.2cm，2DT2：0.5±1.0cm，p=0.9）无差异。序列之间肿瘤、骨髓和脂肪的 SNR 无差异，而肌肉的 SNR 较高（p<0.05）。3DT2 的 CNR 测量值与 2DT2 相似（p>0.1）。与 2DT2 相比，3DT2 的平均采集时间更短（343±127s 与 475±162s，分别）。
与常规 2DT2 二维 MRI 相比，各向同性 3DT2 MRI 具有更高的空间分辨率、更快的采集时间，并能对软组织肿瘤的内在和肿瘤周围特征进行等效评估。3DT2 可在肿瘤方案中替代 2DT2 序列。
各向同性 3DT2 CAIPIRINHA SPACE TSE 比 2DT2 TSE 具有更高的空间分辨率，并且在评估软组织肿瘤内在和肿瘤周围特征方面与 2DT2 TSE 相当。
3DT2 CAIPIRINHA SPACE TSE 的多平面重建可以替代在多个平面采集的 2DT2 TSE，从而缩短 MRI 肿瘤方案的采集时间。
3DT2 CAIPIRINHA SPACE TSE 和 2DT2 TSE 的组织 CNR 相似。
