Uwai Yuichi, Nabekura Tomohiro
School of Pharmacy, Aichi Gakuin University, 1-100, Kusumoto, Chikusa, Nagoya 464-8650, Japan.
School of Pharmacy, Aichi Gakuin University, 1-100, Kusumoto, Chikusa, Nagoya 464-8650, Japan.
Psychiatry Res. 2022 Aug;314:114687. doi: 10.1016/j.psychres.2022.114687. Epub 2022 Jun 19.
The present study attempted to identify risk factors for Parkinson-like events using the Japanese adverse drug event report database. A total of 3521 patients with bipolar disorders were extracted from the database, and Parkinson-like events were detected in 111 (3.15%) using the standardized Medical Dictionary for Regulatory Activities queries. A multiple logistic regression analysis identified age ≥50 years and the use of sodium valproate or aripiprazole as risk factors. Lithium carbonate was not associated with an increased risk of Parkinson-like events, but was related to these events in patients taking sodium valproate.
本研究试图利用日本药品不良事件报告数据库确定帕金森样事件的风险因素。从该数据库中提取了总共3521例双相情感障碍患者，使用标准化的监管活动医学词典查询，在111例（3.15%）患者中检测到帕金森样事件。多因素logistic回归分析确定年龄≥50岁以及使用丙戊酸钠或阿立哌唑为风险因素。碳酸锂与帕金森样事件风险增加无关，但与服用丙戊酸钠的患者发生这些事件有关。
