Department of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
J Mol Cell Cardiol. 2022 Sep;170:117-120. doi: 10.1016/j.yjmcc.2022.06.005. Epub 2022 Jun 23.
Recent advances the cardiac biomedical sciences have been propelled forward by the development and implementation of human iPSC-derived cardiac muscle. These notable successes notwithstanding, it is well recognized in the field that a major roadblock persists in the lack of full "adult cardiac muscle-like" maturation of hiPSC-CMs. This Perspective centers focus on maturation roadblocks in the essential physiological unit of muscle, the sarcomere. Stalled sarcomere maturation must be addressed and overcome before this elegant experimental platform can reach the mountaintop of making impactful contributions in disease pathogenesis, drug discovery, and in clinical regenerative medicine.
近年来，通过开发和应用人类诱导多能干细胞（hiPSC）衍生的心肌细胞，推动了心脏生物医学科学的发展。尽管取得了这些显著的成功，但该领域也充分认识到，hiPSC-CMs 仍存在一个主要的成熟障碍，即缺乏完全的“成人心肌样”成熟。本观点主要关注肌肉的基本生理单位——肌节中的成熟障碍。在这个优雅的实验平台能够在疾病发病机制、药物发现和临床再生医学方面做出有意义的贡献之前，必须解决和克服肌节成熟停滞的问题。
