State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, China; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, China.
Sci Total Environ. 2022 Oct 20;844:156884. doi: 10.1016/j.scitotenv.2022.156884. Epub 2022 Jun 23.
The potential health effects of microplastics (MPs) have become a public concern due to their ubiquitousness in the environment and life. Numerous studies have demonstrated that a high dose of MPs can adversely affect gastrointestinal health. However, few studies have focused on the impact of microplastics on patients' health with respect to gastrointestinal diseases. Inflammatory bowel disease (IBD) has emerged as a global disease with a rapidly increasing incidence. IBD, a specific gastrointestinal illness characterized by acute, chronic inflammation and intestinal barrier dysfunction, might increase sensitivity to MPs exposure. Herein, we investigated the impact and mechanism of PS-MPs on dextran sodium sulfate (DSS)-induced colitis. The results demonstrated that gavage with PS-MPs alone caused minimal effects on the intestinal barrier and liver status of mice. For mice with colitis, additional PS-MPs exposure caused a shorter colon length, aggravated histopathological damage and inflammation, reduced mucus secretion, and increased the colon permeability. Furthermore, PS-MPs exposure also increased the risk of secondary liver injury associated with inflammatory cell infiltration. These findings provide more histopathological evidence and suggest a need for more research on the health risk of MPs for sensitive individuals.
由于微塑料（MPs）在环境和生活中无处不在，其潜在的健康影响已成为公众关注的焦点。大量研究表明，高剂量的 MPs 会对胃肠道健康产生不良影响。然而，很少有研究关注微塑料对胃肠道疾病患者健康的影响。炎症性肠病（IBD）已成为一种全球疾病，其发病率呈快速上升趋势。IBD 是一种特定的胃肠道疾病，其特征为急性、慢性炎症和肠道屏障功能障碍，可能会增加对 MPs 暴露的敏感性。在此，我们研究了 PS-MPs 对葡聚糖硫酸钠（DSS）诱导的结肠炎的影响及其机制。结果表明，PS-MPs 单独灌胃对小鼠的肠道屏障和肝脏状态几乎没有影响。对于患有结肠炎的小鼠，额外的 PS-MPs 暴露会导致结肠长度缩短，组织病理学损伤和炎症加重，黏液分泌减少，结肠通透性增加。此外，PS-MPs 暴露还会增加与炎症细胞浸润相关的继发性肝损伤的风险。这些发现提供了更多的组织病理学证据，并表明需要对 MPs 对敏感个体的健康风险进行更多的研究。
