Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.
Science Experiment Center of China Medical University, Shenyang, 110122, China.
Cell Commun Signal. 2022 Jun 25;20(1):97. doi: 10.1186/s12964-022-00904-5.
Cancer progression involves several biological steps where angiogenesis is a key tumorigenic phenomenon. Extracellular vesicles (EVs) derived from tumor cells and other cells in the tumor microenvironment (TME) help modulate and maintain favorable microenvironments for tumors. Endothelial cells (ECs) activated by cancer-derived EVs have important roles in tumor angiogenesis. Interestingly, EVs from ECs activate tumor cells, i.e. extracellular matrix (ECM) remodeling and provide more supplements for tumor cells. Thus, EV communications between cancer cells and ECs may be effective therapeutic targets for controlling cancer progression. In this review, we describe the current knowledge on EVs derived from ECs and we examine how these EVs affect TME remodeling. Video abstract.
癌症进展涉及几个生物学步骤，其中血管生成是一个关键的肿瘤现象。肿瘤细胞和肿瘤微环境（TME）中的其他细胞衍生的细胞外囊泡（EVs）有助于调节和维持有利于肿瘤的微环境。癌细胞衍生的 EV 激活的内皮细胞（ECs）在肿瘤血管生成中起重要作用。有趣的是，来自 ECs 的 EV 可激活肿瘤细胞，即细胞外基质（ECM）重塑，并为肿瘤细胞提供更多的补充物。因此，癌细胞和 ECs 之间的 EV 通讯可能是控制癌症进展的有效治疗靶点。在这篇综述中，我们描述了来自 ECs 的 EV 的最新知识，并研究了这些 EV 如何影响 TME 的重塑。视频摘要。
