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癌症液体活检中细胞外囊泡多组学分析的临床影响

Clinical Impact of Multi-omics profiling of extracellular vesicles in cancer Liquid Biopsy.

作者信息

Kulkarni Mrunal, Kar Rishav, Ghosh Srestha, Sonar Swarup, Mirgh Divya, Sivakumar Indra, Nayak Abhijit, Muthusamy Raman

机构信息

Department of Pharmacy, BITS Pilani, Rajasthan, 333031, India.

School of Biological Sciences, Ramakrishna Mission Vivekananda Educational and Research Institute (RKMVERI), Kolkata, 700026, India.

出版信息

J Liq Biopsy. 2024 Jan 4;3:100138. doi: 10.1016/j.jlb.2024.100138. eCollection 2024 Mar.

Abstract

Extracellular vesicles (EVs) are the cell's secreted component. It is majorly classified into microvesicles, apoptotic bodies, and exosomes. Exosomes play a significant role in cancer development and progression. Its molecular signature (DNA, RNA, Proteins, lipids) has more priority in cancer profiling current decade. In cancer prevention, the most challenging part is early detection. EVs-based cancer screening develops a promising platform. Multi-Omics exosomes profiling-based liquid biopsy support early cancer detection more efficient way. This approach provides detailed molecular expression data (it may be inner cargos or surface express molecules). This article highlited multi-omic exosome profiling-based exosome theranostics applications in cancer, technical challenges, and improvisation for future improvement.

摘要

细胞外囊泡(EVs)是细胞分泌的成分。它主要分为微囊泡、凋亡小体和外泌体。外泌体在癌症的发生和发展中起着重要作用。在当前十年的癌症分析中,其分子特征(DNA、RNA、蛋白质、脂质)更为重要。在癌症预防中,最具挑战性的部分是早期检测。基于EVs的癌症筛查开发了一个有前景的平台。基于多组学外泌体分析的液体活检以更有效的方式支持早期癌症检测。这种方法提供详细的分子表达数据(可能是内部货物或表面表达分子)。本文重点介绍了基于多组学外泌体分析的外泌体治疗诊断在癌症中的应用、技术挑战以及未来改进的措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c21b/11863700/17dac2ec7bef/gr1.jpg

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