Department of Emergency Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.
Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.
Transfusion. 2022 Aug;62 Suppl 1:S211-S217. doi: 10.1111/trf.16981. Epub 2022 Jun 26.
There is an increasing literature demonstrating the benefits of prehospital and early in-hospital transfusions. RhD-positive products might only be available during these phases, which could pose consequences for future pregnancies if D-alloimmunization occurs. This survey measured the willingness of females to accept urgent but incompatible transfusions in light of the potential for future pregnancy complications.
A survey was designed to assess the willingness of females ≥18 years of age to accept urgent incompatible transfusions when different absolute risk reductions in maternal mortality were presented along with a static rate of 0.3%-4.0% risk of harm to future pregnancies. The survey was sent electronically to women who are part of the Washington University Research Enhancement Core database.
A total of 4896 delivered survey email invitations were distributed and 325 (6.6%) responses were received; 16 responses were excluded leaving 309 responses for analysis. Most of the responding women were White, college-educated, and lived in Missouri. At least 90% of the respondents would accept an urgent incompatible transfusion when the absolute risk reduction in maternal mortality was ≥4%. Women without a college degree, who lived in Illinois, who were not able to have children appeared to be less willing than their counterparts to receive an incompatible transfusion when the absolute risk reduction in maternal mortality was low.
This survey demonstrated that adult women are highly likely to be open to accept urgent incompatible blood transfusions during a bleeding emergency when the absolute risk reduction in maternal mortality was ≥4%.
越来越多的文献证明了院前和早期院内输血的益处。在这些阶段，可能只有 RhD 阳性产品可用，如果发生 D 同种免疫，可能会对未来的妊娠产生影响。这项调查衡量了女性在考虑未来妊娠并发症的情况下，对接受紧急但不相容输血的意愿。
设计了一项调查，以评估≥18 岁的女性在不同的孕产妇死亡率绝对降低率与未来妊娠 0.3%-4.0%的伤害风险率的情况下，对接受紧急不相容输血的意愿。该调查通过电子邮件发送给华盛顿大学研究增强核心数据库的女性。
共发放了 4896 份已交付的调查电子邮件邀请，收到了 325 份（6.6%）回复；排除了 16 份回复，留下 309 份回复进行分析。大多数回复的女性是白人，受过大学教育，居住在密苏里州。当孕产妇死亡率的绝对降低率≥4%时，至少有 90%的受访者会接受紧急不相容输血。没有大学学历、居住在伊利诺伊州、不能生育的女性，当孕产妇死亡率的绝对降低率较低时，她们似乎比同龄人更不愿意接受不相容输血。
这项调查表明，成年女性在孕产妇死亡率的绝对降低率≥4%的紧急出血情况下，极有可能愿意接受紧急不相容的血液输血。
