Ray A, Alkondon M, Sen P
Pharmacol Biochem Behav. 1987 Feb;26(2):229-34. doi: 10.1016/0091-3057(87)90110-9.
(+/-)Propranolol (1, 3, 10 and 30 mg/kg) exhibited a differential effect on footshock aggression (FSA) in rats. Lower doses (1 and 3 mg/kg) of the drug facilitated FSA, whereas an inhibitory effect was observed with higher doses (10 and 30 mg/kg) of the same. (+)Propranolol (30 mg/kg) and UM-272 (1 and 10 mg/kg) as well as physostigmine (0.1 and 0.5 mg/kg) all produced inhibition of FSA. Similar FSA inhibitory effects were also observed with salbutamol (1 and 5 mg/kg). Pretreatment with atropine and not methylatropine attenuated the anti-aggressive effect of (+/-)propranolol (10 mg/kg) without appreciably altering the facilitatory effect (1 mg/kg) of the drug on FSA. In addition, at the anti-aggressive doses, (+/-)propranolol (10 mg/kg) and UM-272 (10 mg/kg), significantly inhibited brain cholinesterase enzyme activity when compared to saline controls. (+/-)Propranolol (10 mg/kg) also inhibited significantly the aggression induced by reserpine-apomorphine treatment. It is inferred that a central cholinergic and dopaminergic mechanism is involved in the anti-aggressive effect of (+/-)propranolol, whereas the low dose induced facilitation of affective aggression could be attributed to central beta-adrenoceptor blockade.
（±）普萘洛尔（1、3、10和30毫克/千克）对大鼠足部电击攻击行为（FSA）表现出不同的影响。较低剂量（1和3毫克/千克）的该药物促进FSA，而相同药物的较高剂量（10和30毫克/千克）则观察到抑制作用。（+）普萘洛尔（30毫克/千克）、UM - 272（1和10毫克/千克）以及毒扁豆碱（0.1和0.5毫克/千克）均产生FSA抑制作用。沙丁胺醇（1和5毫克/千克）也观察到类似的FSA抑制作用。用阿托品而非甲基阿托品预处理可减弱（±）普萘洛尔（10毫克/千克）的抗攻击作用，而不会明显改变该药物对FSA的促进作用（1毫克/千克）。此外，在抗攻击剂量下，与生理盐水对照组相比，（±）普萘洛尔（10毫克/千克）和UM - 272（10毫克/千克）显著抑制脑胆碱酯酶活性。（±）普萘洛尔（10毫克/千克）也显著抑制利血平 - 阿扑吗啡治疗诱导的攻击行为。据推测，中枢胆碱能和多巴胺能机制参与了（±）普萘洛尔的抗攻击作用，而低剂量诱导的情感攻击促进作用可能归因于中枢β - 肾上腺素能受体阻断。
