Srivastava S K, Nath C, Sinha J N
Department of Pharmacology, P.S. Medical College Karamsad, Kheda, India.
Pharmacol Res. 1997 May;35(5):435-8. doi: 10.1006/phrs.1997.0149.
The effect of calcium channel blockers on foot shock induced (aggression (FSA) were studied in mice. Verapamil, (10, 20 and 40 mg kg-1 i.p.) diltiazem (20 and 40 mg kg-1 i.p.) and nifedipine (25 and 50 mg kg-1 i.p.) significantly reduced fighting episodes. Diltiazem and nifedipine blocked the amphetamine induced facilitation of FSA, while verapamil blocked both amphetamine as well as physostigmine induced facilitation of FSA. These findings suggest that calcium channel blockers possess antiaggressive activity, which may be attributed to decrease in central dopaminergic and/or cholinergic mechanism.
研究了钙通道阻滞剂对小鼠足部电击诱导攻击行为（FSA）的影响。维拉帕米（腹腔注射10、20和40mg/kg）、地尔硫卓（腹腔注射20和40mg/kg）和硝苯地平（腹腔注射25和50mg/kg）显著减少了打斗次数。地尔硫卓和硝苯地平阻断了苯丙胺诱导的FSA促进作用，而维拉帕米既阻断了苯丙胺也阻断了毒扁豆碱诱导的FSA促进作用。这些发现表明钙通道阻滞剂具有抗攻击活性，这可能归因于中枢多巴胺能和/或胆碱能机制的降低。
