Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Hans-Meerwein-Str. 6, 35032 Marburg, Germany.
Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Hans-Meerwein-Str. 6, 35032 Marburg, Germany.
J Affect Disord. 2022 Sep 1;312:122-127. doi: 10.1016/j.jad.2022.06.050. Epub 2022 Jun 23.
The diathesis-stress model of major depressive disorder (MDD) predicts interactions of recent stressful life events (SLEs) in adulthood and early developmental risk factors. We tested, for the first time, the diathesis stress model on brain structure in a large group of MDD patients.
Structural magnetic resonance imaging data of 1465 participants (656 with lifetime diagnosis MDD; 809 healthy controls) were analyzed using voxel-based morphometry to identify clusters associated with recent SLEs (Life Events Questionnaire). Those clusters were then examined for group (healthy/MDD) × early developmental risk (operationalized as childhood abuse [Childhood Trauma Questionnaire] and a major psychiatric disorder [i.e., MDD, bipolar disorder, schizophrenia, and schizoaffective disorder] in a first-degree relative) × recent SLEs three-way interactions on grey matter volume.
There was a group × childhood abuse × recent SLEs interaction on left medial orbitofrontal cortex grey matter volume. This three-way interaction arose because childhood abuse and recent SLEs interacted in MDD subjects but not in healthy subjects.
We are not able to draw conclusions about the cause and effect relationship due to our cross-sectional study design.
Our data provides evidence for an interplay between orbitofrontal cortex structure, childhood abuse and recent SLEs. These factors have previously been linked to MDD and their complex interaction contributes to the pathogenesis of MDD.
重性抑郁障碍（MDD）的素质-应激模型预测了成年期和早期发育风险因素的近期生活应激事件（SLEs）的相互作用。我们首次在一大群 MDD 患者中测试了该素质-应激模型对大脑结构的影响。
使用基于体素的形态测量学分析了 1465 名参与者（656 名有终生诊断为 MDD；809 名健康对照者）的结构磁共振成像数据，以识别与近期 SLE（生活事件问卷）相关的聚类。然后检查这些聚类在灰质体积上的组（健康/MDD）×早期发育风险（操作化为童年期虐待[童年创伤问卷]和一级亲属中的重大精神疾病[即 MDD、双相情感障碍、精神分裂症和分裂情感障碍]）×近期 SLEs 的三向交互作用。
在左内侧眶额皮质的灰质体积上存在组×童年虐待×近期 SLEs 的三向交互作用。这种三向相互作用是因为童年虐待和近期 SLE 在 MDD 患者中相互作用，而在健康受试者中则没有。
由于我们的横断面研究设计，我们无法得出关于因果关系的结论。
我们的数据提供了眶额叶皮质结构、童年期虐待和近期 SLEs 之间相互作用的证据。这些因素以前与 MDD 有关，它们的复杂相互作用导致了 MDD 的发病机制。
