Departamento de Ciencias Morfológicas y Sociosanitarias, Facultad de Medicina y Enfermería, Universidad de Córdoba, Córdoba, Spain.
Servicio de Anatomía Patológica, Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain.
Cir Esp (Engl Ed). 2022 Oct;100(10):622-628. doi: 10.1016/j.cireng.2022.06.034. Epub 2022 Jun 23.
The main objective is to establish the overall survival and disease-free survival profiles regarding the patients with retroperitoneal liposarcoma, making a comparison based on the well-differentiated and dedifferentiated histological subtypes. The secondary objectives are to descriptively analyze the clinical characteristics of said patients and to identify and analyze other independent variables that might modify these survival profiles significantly.
An observational and analytical study was performed using a retrospective historical cohort that was followed prospectively. The inclusion criteria consisted of: the procedure of liposarcoma located in the retroperitoneum, the well-differentiated and dedifferentiated histological subtypes, between January of 2002 and May of 2019. As a result, 32 patients took part in this study's sample. Kaplan-Meier estimator was used to summarise the results and log-rank test was used in the comparative analysis.
The overall survival at 5 years was around 59%. No differences were found between the patients with a well-differentiated subtype compared to the dedifferentiated ones (p = 0.834). The disease-free survival at 2 years was 59% regarding the well-differentiated and 26% regarding the dedifferentiated, with these differences being statistically significant (p = 0.005). None of the other studied variables modified these survival profiles significantly.
Dedifferentiated retroperitoneal liposarcomas show less disease-free survival than well-differentiated liposarcomas. However, regarding overall survival no differences can be claimed.
本研究旨在建立腹膜后脂肪肉瘤患者的总生存和无病生存曲线，并基于高分化和去分化组织学亚型进行比较。次要目标是对这些患者的临床特征进行描述性分析，并确定和分析可能显著改变这些生存曲线的其他独立变量。
本研究采用回顾性历史队列的观察性和分析性研究方法，前瞻性随访。纳入标准为：腹膜后脂肪肉瘤手术、高分化和去分化组织学亚型、2002 年 1 月至 2019 年 5 月。最终，共有 32 名患者纳入本研究样本。采用 Kaplan-Meier 估计法总结结果，采用对数秩检验进行比较分析。
5 年总生存率约为 59%。高分化组与去分化组患者之间无差异（p=0.834）。高分化组和去分化组的 2 年无病生存率分别为 59%和 26%，差异具有统计学意义（p=0.005）。其他研究变量均未显著改变这些生存曲线。
去分化腹膜后脂肪肉瘤的无病生存率低于高分化脂肪肉瘤。然而，在总生存率方面，没有差异。
