Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel; The Skin Research Institute, The Dead Sea and Arava Science Center, Masada, 86910, Israel.
Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
Free Radic Biol Med. 2022 Aug 1;188:262-276. doi: 10.1016/j.freeradbiomed.2022.06.238. Epub 2022 Jun 23.
The skin barrier and its endogenous protective mechanisms cope daily with exogenous stressors, of which ultraviolet radiation (UVR) poses an imminent danger. Although the skin is able to reduce the potential damage, there is a need for comprehensive strategies for protection. This is particularly important when developing pharmacological approaches to protect against photocarcinogenesis. Activation of NRF2 has the potential to provide comprehensive and long-lasting protection due to the upregulation of numerous cytoprotective downstream effector proteins that can counteract the damaging effects of UVR. This is also applicable to photodermatosis conditions that exacerbate the damage caused by UVR. This review describes the alterations caused by UVR in normal skin and photosensitive disorders, and provides evidence to support the development of NRF2 activators as pharmacological treatments. Key natural and synthetic activators with photoprotective properties are summarized. Lastly, the gap in knowledge in research associated with photodermatosis conditions is highlighted.
皮肤屏障及其内源性保护机制每天都要应对外源性应激源，其中紫外线辐射（UVR）构成迫在眉睫的危险。尽管皮肤能够减少潜在的损伤，但仍需要全面的保护策略。当开发药理学方法来预防光致癌时，这一点尤为重要。由于 NRF2 的激活能够上调许多细胞保护下游效应蛋白，从而抵消 UVR 的破坏作用，因此具有提供全面和持久保护的潜力。这也适用于使 UVR 引起的损伤恶化的光皮肤病。这篇综述描述了 UVR 在正常皮肤和光敏性疾病中的改变，并提供了支持将 NRF2 激活剂作为药物治疗开发的证据。总结了具有光保护特性的关键天然和合成激活剂。最后，强调了与光皮肤病相关的研究中知识差距。
