Elliott P J, Rosen G M, Nemeroff C B
Pharmacol Biochem Behav. 1987 Mar;26(3):573-5. doi: 10.1016/0091-3057(87)90168-7.
Intraventricular and intraperitoneal administration of cocaine and its metabolite norcocaine were studied in adult male rats. Norcocaine (10-100 micrograms) had no behavioral activity following central infusion but proved to be toxic at high doses (50-100 mg/kg) when given peripherally. Cocaine at high doses (100 micrograms), produced possible hypoactivity after central injections but produced significant hyperactivity after peripheral administration (20 mg/kg).
在成年雄性大鼠中研究了可卡因及其代谢产物去甲可卡因的脑室内和腹腔内给药情况。去甲可卡因（10 - 100微克）经中枢注射后没有行为活性，但外周给药时在高剂量（50 - 100毫克/千克）下被证明具有毒性。高剂量（100微克）的可卡因经中枢注射后可能产生活动减退，但外周给药（20毫克/千克）后产生明显的活动亢进。
