[The influence of method/apparatus conditions on the in vitro liberation of drugs from suppositories].

The examination and evaluation of three experimental designs for the registration of the in-vitro availability of drugs from suppositories--evaluated by using four suppository preparations--showed the special aptitude of a modified model with a large membrane. This model which considers the spreading of the suppository under load, enables one to characterize the in-vitro drug release even for preparations with a low rate of liberation and it provides correct references to bioavailability.