Bornschein M
Pharmazie. 1986 Dec;41(12):852-4.
The examination and evaluation of three experimental designs for the registration of the in-vitro availability of drugs from suppositories--evaluated by using four suppository preparations--showed the special aptitude of a modified model with a large membrane. This model which considers the spreading of the suppository under load, enables one to characterize the in-vitro drug release even for preparations with a low rate of liberation and it provides correct references to bioavailability.
通过使用四种栓剂制剂对三种用于记录栓剂体外药物释放度的实验设计进行的检查和评估表明，一种带有大膜的改良模型具有特殊的适用性。该模型考虑了栓剂在负载下的扩散情况，即使对于释放速率较低的制剂，也能够对体外药物释放进行表征，并且能为生物利用度提供正确的参考。
