[甲喹酮-1-氧化物的体外和体内光化学反应性]
[In vitro and in vivo photochemical reactivity of methaqualone-1-oxide].
作者信息
Pöhlmann H, Theil F P, Franke P, Pfeifer S
出版信息
Pharmazie. 1986 Dec;41(12):856-8.
PMID:3575389
Abstract
Methaqualone-1-oxide (1) exhibits photochemical reactivity. By irradiation of 1 with solar light the oxaziridin 3 is formed at first, which reacts in vitro (human proteins) and in vivo (rats) with macromolecules. As result of the photochemical in vitro and in vivo reactions of 1 the photoproduct 2-acetamidobenzoic acid-2'-methylanilide (6), involved in oxidation of protic compounds, was detected and after hydrolysis of proteins it appears that the short-lived 3 was adding to proteins.
摘要
甲喹酮-1-氧化物（1）表现出光化学反应性。用太阳光照射1时，首先形成恶唑烷3，其在体外（人体蛋白质）和体内（大鼠）与大分子发生反应。由于1的体外和体内光化学反应，检测到参与质子化合物氧化的光产物2-乙酰氨基苯甲酸-2'-甲基苯胺（6），并且在蛋白质水解后发现寿命短暂的3加成到了蛋白质上。
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