Theil F P, Pöhlmann H, Pfeifer S, Franke P
Pharmazie. 1985 May;40(5):328-31.
The photoreactivity of methaqualone-1-oxide a main metabolite of the hypnotic methaqualone has been studied in polar and apolar solvents using UV- and daylight. Five photoproducts were isolated and identified by their analytical behaviour (TLC, UV, IR, high-resolution MS). The structure of the compounds 4, 6, 7, and 8 refer to unstable, reactive intermediates (oxaziridine, biradical) during the photolysis.
安眠酮的主要代谢产物甲喹酮-1-氧化物在极性和非极性溶剂中利用紫外线和日光进行了光反应性研究。分离出了五种光产物,并通过其分析行为(薄层色谱法、紫外线、红外光谱、高分辨率质谱)进行了鉴定。化合物4、6、7和8的结构涉及光解过程中的不稳定反应中间体(氧氮杂环丙烷、双自由基)。