Kéri E, Marton S, Plachy J, Rácz I
Pharmazie. 1987 Jan;42(1):30-2.
The salts of fenoprofen formed with different metals have shown various crystal forms and solubility. The calcium salt has proved the most suitable characteristics for tablet and capsule production. Dissolution and absorption parameters of this substance were studied using in vitro and in vivo methods. The absorption rate and the correlation between pH and membrane diffusion rate constant were investigated in vitro using the "Sartorius" apparatus. The dissolution rate--depending on pH--was investigated by the oscillometric method. The in vivo disintegration of an experimental sample was compared with a commercial preparation. The comparison has been documented by endoscopic photography.
非诺洛芬与不同金属形成的盐呈现出多种晶体形态和溶解性。钙盐已被证明具有最适合片剂和胶囊生产的特性。使用体外和体内方法研究了该物质的溶解和吸收参数。使用“Sartorius”仪器在体外研究了吸收速率以及pH与膜扩散速率常数之间的相关性。通过示波法研究了取决于pH的溶解速率。将实验样品的体内崩解与市售制剂进行了比较。该比较已通过内镜摄影记录下来。
