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RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation.

作者信息

Song Li-Jun, Yin Xu-Ren, Guan Sheng-Wen, Gao Hong, Dong Pan-Pan, Mei Cong-Jin, Yang Ying-Ying, Zhang Ying, Yu Chuan-Xin, Hua Zi-Chun

机构信息

School of Life Sciences and the State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China.

Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, PR China.

出版信息

Signal Transduct Target Ther. 2022 Jun 27;7(1):193. doi: 10.1038/s41392-022-01019-6.

DOI:10.1038/s41392-022-01019-6
PMID:35754047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9234041/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/9234041/dcccd25ab7b2/41392_2022_1019_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/9234041/dcccd25ab7b2/41392_2022_1019_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/9234041/dcccd25ab7b2/41392_2022_1019_Fig1_HTML.jpg

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1
RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation.RIP3缺乏通过下调JNK-cJUN/Egr1减轻血吸虫病中肝星状细胞的激活和肝纤维化。
Signal Transduct Target Ther. 2022 Jun 27;7(1):193. doi: 10.1038/s41392-022-01019-6.
2
Artesunate alleviates schistosomiasis-induced liver fibrosis by downregulation of mitochondrial complex Ⅰ subunit NDUFB8 and complex Ⅲ subunit UQCRC2 in hepatic stellate cells.青蒿琥酯通过下调肝星状细胞中线粒体复合物 Ⅰ亚基 NDUFB8 和复合物 Ⅲ亚基 UQCRC2 缓解血吸虫病肝纤维化。
Acta Trop. 2021 Feb;214:105781. doi: 10.1016/j.actatropica.2020.105781. Epub 2020 Nov 29.
3
MiR-542-3p controls hepatic stellate cell activation and fibrosis via targeting BMP-7.miR-542-3p 通过靶向 BMP-7 控制肝星状细胞活化和纤维化。
J Cell Biochem. 2019 Mar;120(3):4573-4581. doi: 10.1002/jcb.27746. Epub 2018 Oct 28.
4
MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression.microRNA-214 通过抑制 Sufu 表达促进肝星状细胞活化和肝纤维化。
Cell Death Dis. 2018 Jun 18;9(7):718. doi: 10.1038/s41419-018-0752-1.
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MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.微小RNA-130a和-130b通过抑制PPARγ表达增强肝星状细胞的激活：一项大鼠纤维化模型研究
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promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.通过靶向维生素 D 受体促进血吸虫病诱导的肝纤维化。
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The role of JNK signaling pathway in organ fibrosis.

本文引用的文献

1
RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-κB pathway in macrophages.RIP3 缺乏通过抑制巨噬细胞中的 ROCK1-TLR4-NF-κB 通路来减轻肝纤维化。
FASEB J. 2019 Oct 1;33(10):11180-11193. doi: 10.1096/fj.201900752R. Epub 2019 Jul 11.
2
Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress.RIP3 的缺失引发了高脂肪饮食引发的非酒精性肝脂肪变性的消除：一种涉及 Toll 样受体 4 和氧化应激的机制。
Free Radic Biol Med. 2019 Apr;134:23-41. doi: 10.1016/j.freeradbiomed.2018.12.034. Epub 2018 Dec 30.
3
JNK信号通路在器官纤维化中的作用。
J Adv Res. 2025 Aug;74:207-223. doi: 10.1016/j.jare.2024.09.029. Epub 2024 Oct 2.
4
Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model.混合谱系激酶结构域样蛋白在饮食诱导的肥胖、肝脏病理及胰岛素敏感性中的非坏死性作用：来自高脂、高果糖、高胆固醇饮食小鼠模型的见解
Int J Mol Sci. 2024 Feb 28;25(5):2813. doi: 10.3390/ijms25052813.
5
The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by infection involving damage-associated molecular patterns (DAMPs).蛋清核糖核酸酶 SjCP1412 可加速由感染引起的肝纤维化，涉及损伤相关分子模式（DAMPs）。
Parasitology. 2024 Mar;151(3):260-270. doi: 10.1017/S0031182023001361. Epub 2023 Dec 18.
6
Programmed cell death in hepatic fibrosis: current and perspectives.肝纤维化中的程序性细胞死亡：现状与展望
Cell Death Discov. 2023 Dec 12;9(1):449. doi: 10.1038/s41420-023-01749-8.
7
The double-edged functions of necroptosis.细胞坏死性凋亡的双刃剑作用。
Cell Death Dis. 2023 Feb 27;14(2):163. doi: 10.1038/s41419-023-05691-6.
Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury.
受体相互作用蛋白3可保护小鼠免受高脂饮食诱导的肝损伤。
Hepatology. 2016 Nov;64(5):1518-1533. doi: 10.1002/hep.28676. Epub 2016 Jul 17.
4
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality.RIP3介导的坏死性细胞死亡加速全身炎症反应和死亡。
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11007-12. doi: 10.1073/pnas.1514730112. Epub 2015 Aug 17.
5
Liver fibrosis.肝纤维化
J Clin Invest. 2005 Feb;115(2):209-18. doi: 10.1172/JCI24282.