Aguayo Liliana, Ogolsky Brian, Teran-Garcia Margarita, Pineros-Leano María, Wiley Angela, Lin Jue, Aguirre-Pereyra Rosalba, Schwingel Andiara
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Mary Ann & J. Milburn Smith Child Health Research, Outreach, and Advocacy Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital, Chicago, IL, United States.
Compr Psychoneuroendocrinol. 2021 Jan 23;5:100029. doi: 10.1016/j.cpnec.2021.100029. eCollection 2021 Feb.
Studies suggest that telomere lengths, a biomarker of aging, could also capture the physiological weathering attributable to poor health behaviors and adverse experiences, particularly those experienced in early life. For these reasons, we propose that telomere lengths may be a pivotal biomarker for measuring the heightened susceptibility to illness resulting from the cumulative exposure to acculturation to the US culture. This binational study used an Actor-Partner Interdependence Model to test if maternal acculturation to the US moderates the cross-sectional associations of telomere lengths with percentage of body fat (PBF) among Mexican women, among their children, and the intergenerational associations of mother and children telomere lengths with each other's PBF. Low income Mexican child-mother dyads (n = 108 dyads) were recruited to participate in this cross-sectional study in Mexico and the US. The pooled dataset included measurements of maternal acculturation to the US, mother and children's salivary telomere lengths, PBF measured through bioelectrical impedance, and demographic characteristics. Results showed that the influences of maternal acculturation in the associations of telomere lengths with PBF were different for mothers and their children: Among mothers with higher maternal acculturation to the US, longer salivary telomere lengths were associated with lower PBF. In contrast, among mothers with lower maternal acculturation to the US, salivary telomere lengths were not associated with PBF. There were no significant associations between children's salivary telomere lengths and PBF, and the null associations did not vary across different levels of maternal acculturation to the US. Future longitudinal studies are needed to determine whether acculturation to the US (experienced through immigration or remotely) influences the association of telomere length attrition with obesity risks among immigrant and non-immigrant Mexican children and adults.
研究表明，端粒长度作为衰老的生物标志物，也可能反映出因不良健康行为和不良经历，尤其是早年经历所导致的生理老化。基于这些原因，我们提出端粒长度可能是一个关键的生物标志物，用于衡量因长期接触美国文化适应过程而导致的疾病易感性增加。这项双边研究使用了演员-伙伴相互依赖模型，来检验墨西哥裔女性及其子女中，母亲对美国文化的适应程度是否会调节端粒长度与体脂百分比（PBF）之间的横断面关联，以及母亲和子女的端粒长度之间关于彼此PBF的代际关联。低收入的墨西哥儿童-母亲二元组（n = 108个二元组）被招募来参与这项在墨西哥和美国进行的横断面研究。汇总数据集包括母亲对美国文化的适应程度、母亲和子女的唾液端粒长度、通过生物电阻抗测量的PBF以及人口统计学特征的测量值。结果显示，母亲对美国文化的适应程度在端粒长度与PBF关联中的影响，对母亲和她们的孩子来说是不同的：在母亲对美国文化适应程度较高的母亲中，较长的唾液端粒长度与较低的PBF相关。相比之下，在母亲对美国文化适应程度较低的母亲中，唾液端粒长度与PBF无关。儿童的唾液端粒长度与PBF之间没有显著关联，并且这种无关联在母亲对美国文化不同适应程度水平上没有变化。未来需要进行纵向研究，以确定对美国文化的适应（通过移民或远程方式经历）是否会影响移民和非移民墨西哥儿童及成年人中端粒长度损耗与肥胖风险之间的关联。
