Ryan-Harshman M, Leiter L A, Anderson G H
Physiol Behav. 1987;39(2):247-53. doi: 10.1016/0031-9384(87)90017-5.
Two experiments were designed to investigate the neurobehavioral effects of phenylalanine (PHE; 0.84, 2.52, 5.04, and 10.08 g) and aspartame (APM; 5.04 and 10.08 g) on energy and macronutrient selection and on subjective feelings of hunger, mood and arousal in normal weight adult males. Neither phenylalanine nor aspartame altered mean energy intakes or macronutrient selection at a lunch begun 60 to 105 min after the amino acids were consumed. During this time, increased (p less than 0.05) visual analog scale (VAS) scores for emptiness, rumbling, weakness, degree of hunger and urge to eat were found in both experiments, but no treatment effects or interactions were seen for any variable in either experiment. Plasma PHE levels and ratios to other large neutral amino acids (NAA) rose significantly (p less than 0.05) after all treatments except 0.84 g PHE; plasma tyrosine (TYR) levels increased (p less than 0.05) only when greater than or equal to 2.52 g PHE was given. TYR/NAA ratios were higher (p less than 0.05) after 2.52 and 5.04 g PHE, and 10.08 g APM. No relationships were found between food intake and plasma amino acid levels. We conclude that, in normal weight men, PHE and APM, in doses up to 10 g, do not affect short-term energy and macronutrient intakes, or subjective feelings of hunger, mood and arousal.
设计了两项实验，以研究苯丙氨酸（PHE；0.84、2.52、5.04和10.08克）和阿斯巴甜（APM；5.04和10.08克）对正常体重成年男性的能量和常量营养素选择以及饥饿、情绪和觉醒主观感受的神经行为影响。在摄入氨基酸后60至105分钟开始的午餐中，苯丙氨酸和阿斯巴甜均未改变平均能量摄入量或常量营养素选择。在此期间，两项实验中均发现空虚、肠鸣、虚弱、饥饿程度和进食欲望的视觉模拟量表（VAS）评分增加（p<0.05），但在任何一项实验中，任何变量均未观察到处理效应或交互作用。除0.84克PHE外，所有处理后血浆PHE水平及其与其他大中性氨基酸（NAA）的比率均显著升高（p<0.05）；仅当给予大于或等于2.52克PHE时，血浆酪氨酸（TYR）水平才会升高（p<0.05）。2.52克和5.04克PHE以及10.08克APM后，TYR/NAA比率更高（p<0.05）。未发现食物摄入量与血浆氨基酸水平之间存在关联。我们得出结论，在正常体重男性中，剂量高达10克的PHE和APM不会影响短期能量和常量营养素摄入量，或饥饿、情绪和觉醒的主观感受。
