Shukla Ratnakar, Kandikatla Ashwini, Nadkarni Nitin J, Patil Anant
Department of Dermatology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Department of Dermatology, HBT Medical College and Dr. R N Cooper Municipal General Hospital, Navi Mumbai, Maharashtra, India.
Int J Appl Basic Med Res. 2022 Apr-Jun;12(2):148-150. doi: 10.4103/ijabmr.ijabmr_528_21. Epub 2022 May 10.
Eosinophilic granulomatosis with polyangiitis also known as Churg-Strauss syndrome or allergic granulomatosis and angiitis is an extremely rare systemic necrotizing vasculitis that affects small-to-medium-sized vessels. Here, we report a case of a 58-year-old man presenting with painful swelling of bilateral lower limbs with multiple well-defined erosions on lower legs and dorsum of the foot with a few of them showing brownish crusts and with slight watery discharge and a few with raw areas. The patient is a known case of bronchial asthma. Histopathology of foot and face lesion shows inflammatory cell infiltrate predominantly comprising of eosinophils, small- and medium-sized blood vessels are thickened. P-antineutrophil cytoplasmic antibody positivity was seen. Thus, on the basis of positive findings which satisfy the criteria for eosinophilic granulomatosis with polyangiitis, we diagnosed this as a case of eosinophilic granulomatosis with polyangiitis, and for rarity of this case, we would like to report it.
嗜酸性肉芽肿性多血管炎,也称为变应性肉芽肿性血管炎或Churg-Strauss综合征,是一种极其罕见的系统性坏死性血管炎,可累及中小血管。在此,我们报告一例58岁男性患者,其双下肢出现疼痛性肿胀,小腿和足背有多个边界清晰的糜烂灶,其中一些有褐色痂皮,有少量水样分泌物,还有一些为创面。该患者为已知的支气管哮喘病例。足部和面部病变的组织病理学显示,炎症细胞浸润以嗜酸性粒细胞为主,中小血管增厚。抗中性粒细胞胞浆抗体呈阳性。因此,基于符合嗜酸性肉芽肿性多血管炎标准的阳性发现,我们将此诊断为嗜酸性肉芽肿性多血管炎病例,鉴于该病例的罕见性,我们特此报告。