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嗜酸性肉芽肿性多血管炎

Eosinophilic Granulomatosis with Polyangiitis.

作者信息

Shukla Ratnakar, Kandikatla Ashwini, Nadkarni Nitin J, Patil Anant

机构信息

Department of Dermatology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.

Department of Dermatology, HBT Medical College and Dr. R N Cooper Municipal General Hospital, Navi Mumbai, Maharashtra, India.

出版信息

Int J Appl Basic Med Res. 2022 Apr-Jun;12(2):148-150. doi: 10.4103/ijabmr.ijabmr_528_21. Epub 2022 May 10.

Abstract

Eosinophilic granulomatosis with polyangiitis also known as Churg-Strauss syndrome or allergic granulomatosis and angiitis is an extremely rare systemic necrotizing vasculitis that affects small-to-medium-sized vessels. Here, we report a case of a 58-year-old man presenting with painful swelling of bilateral lower limbs with multiple well-defined erosions on lower legs and dorsum of the foot with a few of them showing brownish crusts and with slight watery discharge and a few with raw areas. The patient is a known case of bronchial asthma. Histopathology of foot and face lesion shows inflammatory cell infiltrate predominantly comprising of eosinophils, small- and medium-sized blood vessels are thickened. P-antineutrophil cytoplasmic antibody positivity was seen. Thus, on the basis of positive findings which satisfy the criteria for eosinophilic granulomatosis with polyangiitis, we diagnosed this as a case of eosinophilic granulomatosis with polyangiitis, and for rarity of this case, we would like to report it.

摘要

嗜酸性肉芽肿性多血管炎,也称为变应性肉芽肿性血管炎或Churg-Strauss综合征,是一种极其罕见的系统性坏死性血管炎,可累及中小血管。在此,我们报告一例58岁男性患者,其双下肢出现疼痛性肿胀,小腿和足背有多个边界清晰的糜烂灶,其中一些有褐色痂皮,有少量水样分泌物,还有一些为创面。该患者为已知的支气管哮喘病例。足部和面部病变的组织病理学显示,炎症细胞浸润以嗜酸性粒细胞为主,中小血管增厚。抗中性粒细胞胞浆抗体呈阳性。因此,基于符合嗜酸性肉芽肿性多血管炎标准的阳性发现,我们将此诊断为嗜酸性肉芽肿性多血管炎病例,鉴于该病例的罕见性,我们特此报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73f8/9215177/3e7523c49cf4/IJABMR-12-148-g001.jpg

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