Wang Xin, Liu Li-Juan, Li Lin-Feng, Shi Xiao-Dong, Shen Yi-Wei
Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Front Med (Lausanne). 2022 Jun 9;9:899857. doi: 10.3389/fmed.2022.899857. eCollection 2022.
The clinical features of urticaria have not been fully illustrated.
To demonstrate clinical features of urticaria in different areas of southern and northern China.
In this hospital-based multicenter study, outpatients with urticaria filled in a questionnaire during the initial visit and follow-up (once per week, lasting for a month).
Overall, 1,715 outpatients with urticaria with a mean age of 37.86 ± 16.08 years (range = 0.5-87 years) were recruited. The median disease duration was 1.94 ± 4.31 years (range = 0-58 years). More itching was observed in the northern areas higher than that in the southern areas (99.5 vs 94.1%, < 0.001). The incidence of pain, arthralgia, and family history in southern areas was higher than that in northern areas (5.1 vs 1.1%, 9.6 vs 0, 10.6% vs 3.2%, < 0.001). The leading subtypes of specified urticaria were chronic spontaneous urticaria (81.4%) and symptomatic dermographism (35.9%). The incidence of symptomatic dermographism and cold urticaria in the southern areas was lower than that in the northern areas (31.8 vs. 50.3%, 4 vs. 8.5%, < 0.001). Allergic diseases were the most common concomitant disorders of urticaria. More than half of the patients had to avoid certain food, such as fish-prawn-crab (30.7%) and alcohol (20%). Ebastine (41.1%) was the most commonly prescribed drug. The disease duration negatively correlated with the severity of itching and number of wheals (>50/24H) (Spearman's rank correlation test, < 0.001).
This study provides a profile of clinical characteristics of urticaria in China and filled the gap in the field of regional comparative studies on urticaria.
荨麻疹的临床特征尚未得到充分阐释。
阐述中国南方和北方不同地区荨麻疹的临床特征。
在这项基于医院的多中心研究中，荨麻疹门诊患者在初诊和随访期间（每周一次，持续一个月）填写问卷。
总体上，招募了1715例荨麻疹门诊患者，平均年龄为37.86±16.08岁（范围=0.5 - 87岁）。疾病中位病程为1.94±4.31年（范围=0 - 58年）。北方地区瘙痒症状比南方地区更明显（99.5%对94.1%，<0.001）。南方地区疼痛、关节痛及家族史的发生率高于北方地区（5.1%对1.1%，9.6%对0，10.6%对3.2%，<0.001）。特定类型荨麻疹的主要亚型为慢性自发性荨麻疹（81.4%）和症状性皮肤划痕症（35.9%）。南方地区症状性皮肤划痕症和寒冷性荨麻疹的发生率低于北方地区（31.8%对50.3%，4%对8.5%，<0.001）。过敏性疾病是荨麻疹最常见的伴随疾病。超过一半的患者不得不避免某些食物，如鱼虾蟹（30.7%）和酒精（20%）。依巴斯汀（41.1%）是最常用的处方药物。病程与瘙痒严重程度及风团数量（>50/24小时）呈负相关（Spearman等级相关检验，<0.001）。
本研究提供了中国荨麻疹临床特征的概况，填补了荨麻疹区域比较研究领域的空白。
