Investigation the Efficacy of Fuzzy Logic Implementation at Image-Guided Radiotherapy.

At image-guided radiotherapy, technique, different imaging, and monitoring systems are utilized for (i) organs border detection and tumor delineation during the treatment planning process and (ii) patient setup and tumor localization at pretreatment step and (iii) real-time tumor motion tracking for dynamic thorax tumors during the treatment. In this study, the effect of fuzzy logic is quantitatively investigated at different steps of image-guided radiotherapy. Fuzzy logic-based models and algorithms have been implemented at three steps, and the obtained results are compared with commonly available strategies. Required data are (i) real patients treated with Synchrony Cyberknife system at Georgetown University Hospital for real-time tumor motion prediction, (ii) computed tomography images taken from real patients for geometrical setup, and also (iii) tomography images of an anthropomorphic phantom for tumor delineation process. In real-time tumor tracking, the targeting error averages of the fuzzy correlation model in comparison with the Cyberknife modeler are 4.57 mm and 8.97 mm, respectively, for a given patient that shows remarkable error reduction. In the case of patient geometrical setup, the fuzzy logic-based algorithm has better influence in comparing with the artificial neural network, while the setup error averages is reduced from 1.47 to 0.4432 mm using the fuzzy logic-based method, for a given patient.Finally, the obtained results show that the fuzzy logic based image processing algorithm exhibits much better performance for edge detection compared to four conventional operators. This study is an effort to show that fuzzy logic based algorithms are also highly applicable at image-guided radiotherapy as one of the important treatment modalities for tumor delineation, patient setup error reduction, and intrafractional motion error compensation due to their inherent properties.