Mu Eveline, Kulkarni Jayashri
Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School and The Alfred Hospital, Melbourne.
Aust Prescr. 2022 Jun;45(3):75-79. doi: 10.18773/austprescr.2022.025. Epub 2022 Jun 1.
Hormonal contraception is known to precipitate or perpetuate depression in some patients. The link between oral contraceptive pills and depression relates to the amount and type of progestogen contained in these pills. Many of the older oral contraceptive pills, which contain ethinylestradiol, are linked to severe mood problems. Newer oral contraceptive pills containing physiological forms of oestrogen may be better tolerated with a purported weaker link to mood problems. Clinicians should consider the temporal relationship between the use of hormonal contraception and development of new or worsened depression or mood changes.
已知激素避孕会在一些患者中引发或加重抑郁症。口服避孕药与抑郁症之间的联系与这些药物中所含孕激素的量和类型有关。许多含有炔雌醇的老式口服避孕药与严重的情绪问题有关。含有生理形式雌激素的新型口服避孕药可能耐受性更好,据称与情绪问题的联系较弱。临床医生应考虑激素避孕的使用与新发或加重的抑郁症或情绪变化之间的时间关系。