抗 VEGF 药物联合曲安奈德玻璃体腔注射治疗 Coats 病的临床研究。
Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease.
机构信息
Department of Ophthalmology, Huangmei People's Hospital, 137 Wuzu Dadao, Huangmei Town, Huangmei County, Huanggang City, Hubei Province 435500, China.
Anesthesiology Department, Caidian District People's Hospital of Wuhan, No. 111 Chenggong Avenue, Caidian District, Wuhan City, Hubei Province 430100, China.
出版信息
Comput Math Methods Med. 2022 Jun 17;2022:9911549. doi: 10.1155/2022/9911549. eCollection 2022.
OBJECTIVE
To investigate the clinical study of intravitreal injection of anti-VEGF drugs combined with intravitreal injection of tretinoin for the treatment of Coats disease.
METHODS
The medical records of 90 patients (120 eyes) with Coats disease admitted to our hospital from April 2010 to June 2021 were selected as retrospective study subjects and divided into control and treatment groups according to the numerical table method. There were 45 cases and 60 eyes in each group. Among them, intravitreal tretinoin drug was injected into the control group, and anti-VEGF drug was injected into the vitreous sclera of the treatment group on the basis of the control group.
RESULTS
Before treatment, the differences in visual acuity changes between the two groups were not statistically significant ( > 0.05). After treatment, the light perception, manipulation, and indexes of both groups were significantly improved, and the treatment group was significantly better than the control group. This difference was statistically significant ( < 0.05) for statistical study comparison. The effective rate of 95.56% in the treatment group was significantly higher than that of 86.67% in the control group, and the complication rate was significantly lower than that of the control group, with statistically significant differences ( < 0.05).
CONCLUSION
Intravitreal injection of anti-VEGF drugs combined with tretinoin injection can significantly improve the clinical efficacy of patients with Coats disease and improve visual acuity and central retinal thickness, which has certain reference value for the clinical treatment of Coats disease.
目的
探讨玻璃体腔注射抗 VEGF 药物联合维 A 酸治疗 Coats 病的临床研究。
方法
选取 2010 年 4 月至 2021 年 6 月我院收治的 90 例（120 眼）Coats 病患者的病历资料进行回顾性研究，采用数字表法分为对照组和治疗组，各 45 例 60 眼。对照组给予玻璃体腔内注射维 A 酸药物，治疗组在对照组基础上给予玻璃体腔注射抗 VEGF 药物。
结果
两组治疗前视力变化差异无统计学意义（>0.05）。两组治疗后光感、手动、指数均有明显改善，且治疗组明显优于对照组，差异有统计学意义（<0.05）。治疗组有效率为 95.56%，明显高于对照组的 86.67%，并发症发生率明显低于对照组，差异均有统计学意义（<0.05）。
结论
玻璃体腔注射抗 VEGF 药物联合维 A 酸治疗 Coats 病可显著提高患者的临床疗效，提高视力和中心视网膜厚度，对 Coats 病的临床治疗具有一定的参考价值。
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