Nguyen Thi D, Truong Melissa E, Reiter Jeremy F
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, United States.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States.
Front Cell Dev Biol. 2022 Jun 9;10:876815. doi: 10.3389/fcell.2022.876815. eCollection 2022.
Hedgehog (HH) signaling is an intercellular communication pathway involved in directing the development and homeostasis of metazoans. HH signaling depends on lipids that covalently modify HH proteins and participate in signal transduction downstream. In many animals, the HH pathway requires the primary cilium, an organelle with a specialized protein and lipid composition. Here, we review the intimate connection between HH signaling and lipids. We highlight how lipids in the primary cilium can create a specialized microenvironment to facilitate signaling, and how HH and components of the HH signal transduction pathway use lipids to communicate between cells.
刺猬信号通路（HH）是一种细胞间通讯途径，参与后生动物的发育和稳态调节。HH信号通路依赖于共价修饰HH蛋白并参与下游信号转导的脂质。在许多动物中，HH信号通路需要初级纤毛，这是一种具有特殊蛋白质和脂质组成的细胞器。在此，我们综述HH信号通路与脂质之间的密切联系。我们强调初级纤毛中的脂质如何能够创造一个特殊的微环境以促进信号传导，以及HH信号转导通路的组成部分如何利用脂质在细胞间进行通讯。
