胆固醇及其衍生物在 Sonic Hedgehog 信号通路与癌症中的作用。
Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer.
机构信息
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
出版信息
Curr Opin Pharmacol. 2012 Dec;12(6):736-41. doi: 10.1016/j.coph.2012.07.002. Epub 2012 Jul 23.
Abstract
The connection between the Hedgehog (HH) pathway and cholesterol has been recognized since the early days that shaped our current understanding of this unique pathway. Cholesterol and related lipids are intricately linked to HH signaling: from the role of cholesterol in HH biosynthesis to the modulation of HH signal reception and transduction by other sterols, passing by the phylogenetic relationships among many components of the HH pathway that resemble or contain lipid-binding domains. Here I review the connections between HH signaling, cholesterol and its derivatives and analyze the potential implications for HH-dependent cancers.
摘要
自早期开始，人们就已经认识到 Hedgehog（HH）途径与胆固醇之间存在联系，这有助于我们当前对该独特途径的理解。胆固醇和相关脂质与 HH 信号密切相关：从胆固醇在 HH 生物合成中的作用，到其他甾醇对 HH 信号接收和转导的调节，再到 HH 途径的许多成分之间的系统发育关系，这些成分类似于或包含脂质结合结构域。在此，我综述了 HH 信号、胆固醇及其衍生物之间的联系，并分析了它们对 HH 依赖性癌症的潜在影响。
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Vitam Horm. 2012;88:55-72. doi: 10.1016/B978-0-12-394622-5.00003-1.
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Dev Cell. 2012 Feb 14;22(2):268-78. doi: 10.1016/j.devcel.2011.11.023.
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PLoS Biol. 2012 Jan;10(1):e1001239. doi: 10.1371/journal.pbio.1001239. Epub 2012 Jan 10.
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Nat Chem Biol. 2012 Jan 8;8(2):211-20. doi: 10.1038/nchembio.765.
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Anat Cell Biol. 2011 Sep;44(3):204-9. doi: 10.5115/acb.2011.44.3.204. Epub 2011 Sep 29.
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