Nolde Janis M, Connor Sophia G, Al-Zubaidi Arkan, Obst Martina A, Laupenmühlen Jana, Heldmann Marcus, Jauch-Chara Kamila, Münte Thomas F
Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
School of Medicine, University of Western Australia, Perth, Australia.
Compr Psychoneuroendocrinol. 2021 Mar 29;6:100055. doi: 10.1016/j.cpnec.2021.100055. eCollection 2021 May.
The communication between brain and peripheral homeostatic systems is a central element of ingestive control. We set out to explore which parts of the brain have strong functional connections to peripheral signalling molecules in a physiological context. It was hypothesised that associations can be found between endocrine response to glucose ingestion and preceding brain activity in dependence of the nutritional status of the body.
Young, healthy male participants underwent both a 38 h fasting and a control condition with standardized meals. On the second day of the experiment, participants underwent fMRI scanning followed by ingestion of glucose solution in both conditions. Subsequent endocrine responses relevant to energy metabolism were assessed. Associations between preceding brain activation and endocrine responses were examined.
In both fasting and non-fasting conditions, brain activity was associated with subsequent endocrine responses after glucose administration, but relevant brain areas differed substantially between the conditions. In the fasting condition relations between the caudate nucleus and the orbitofrontal regions with insulin and C-peptide were prevailing, whereas in the non-fasting condition associations between various brain regions and adiponectin and cortisol were the predominant significant outcome.
Connections between endocrine response following a glucose challenge and prior brain activity suggests that the brain is playing an active role in the networks regulating food intake and associated endocrine signals. Further studies are needed to demonstrate causation.
大脑与外周稳态系统之间的通讯是摄食控制的核心要素。我们着手探究在生理背景下大脑的哪些部分与外周信号分子具有强大的功能连接。据推测，根据身体的营养状况，在对葡萄糖摄入的内分泌反应与先前的大脑活动之间可以发现关联。
年轻健康的男性参与者经历了38小时禁食和标准化餐食的对照情况。在实验的第二天，参与者在两种情况下都接受了功能磁共振成像扫描，随后摄入葡萄糖溶液。评估了与能量代谢相关的后续内分泌反应。检查了先前大脑激活与内分泌反应之间的关联。
在禁食和非禁食条件下，大脑活动都与葡萄糖给药后的后续内分泌反应相关，但不同条件下相关的脑区有很大差异。在禁食条件下，尾状核和眶额叶区域与胰岛素和C肽之间的关系占主导，而在非禁食条件下，各个脑区与脂联素和皮质醇之间的关联是主要的显著结果。
葡萄糖刺激后的内分泌反应与先前大脑活动之间的联系表明，大脑在调节食物摄入和相关内分泌信号的网络中发挥着积极作用。需要进一步研究来证明因果关系。
