Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.
Institute of Psychology, Department of Methodology and Statistics, Leiden University, Leiden, Netherlands.
Nutr Neurosci. 2020 Feb;23(2):110-117. doi: 10.1080/1028415X.2018.1477538. Epub 2018 May 27.
The regulatory role of the brain in directing eating behavior becomes increasingly recognized. Although many areas in the brain have been found to respond to food cues, very little data is available after actual caloric intake. The aim of this study was to determine normal whole brain functional responses to ingestion of glucose after an overnight fast. Twenty-five normal weight, adult males underwent functional MRI on two separate visits. In a single-blind randomized study setup, participants received either glucose solution (50 g/300 ml of water) or plain water. We studied changes in Blood Oxygen Level Dependent (BOLD) signal, voxel-based connectivity by Eigenvector Centrality Mapping, and functional network connectivity. Ingestion of glucose led to increased centrality in the thalamus and to decreases in BOLD signal in various brain areas. Decreases in connectivity in the sensory-motor and dorsal visual stream networks were found. Ingestion of water resulted in increased centrality across the brain, and increases in connectivity in the medial and lateral visual cortex network. Increased BOLD intensity was found in the intracalcarine and cingulate cortex. Our data show that ingestion of glucose leads to decreased activity and connectivity in brain areas and networks linked to energy seeking and satiation. In contrast, drinking plain water leads to increased connectivity probably associated with continued food seeking and unfulfilled reward. This study combines data of two studies registered at clinicaltrails.gov under numbers NCT03202342 and NCT03247114.
大脑在指导进食行为方面的调节作用正越来越受到重视。虽然已经发现大脑的许多区域对食物线索有反应，但在实际摄入热量后，可用的数据却很少。本研究旨在确定正常体重的成年男性在禁食一夜后摄入葡萄糖时大脑的整体功能反应。25 名正常体重的成年男性在两次单独就诊时接受了功能磁共振成像检查。在一项单盲随机研究设计中，参与者接受了葡萄糖溶液（50g/300ml 水）或白开水。我们研究了葡萄糖摄入后血氧水平依赖（BOLD）信号、基于特征向量中心性映射的体素连接性以及功能网络连接性的变化。葡萄糖摄入导致丘脑的中心性增加，以及大脑各个区域的 BOLD 信号减少。还发现感觉运动和背侧视觉流网络的连接性降低。饮水导致大脑各处的中心性增加，以及内侧和外侧视觉皮质网络的连接性增加。在距状回和扣带回皮质内发现 BOLD 强度增加。我们的数据表明，葡萄糖摄入会导致与能量寻求和饱腹感相关的大脑区域和网络的活动和连接性降低。相比之下，饮用白开水会导致连接性增加，可能与持续的食物寻求和未满足的奖励有关。本研究结合了在 clinicaltrails.gov 下注册的两项研究的数据，编号为 NCT03202342 和 NCT03247114。
