[生长激素刺激试验及胰岛素样生长因子1在生长激素缺乏症中的诊断意义及注意事项]
[Diagnostic significance and considerations of growth hormone stimulation testing and insulin-like growth factor 1 in growth hormone deficiency].
作者信息
Li Tang
机构信息
Department of Pediatric Endocrinology and Metabolism, Women and Children's Hospital, Qingdao University, Qingdao, Shandong 266000, China (Email: drlitang@hotmail. com).
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Dec 15;25(12):1193-1197. doi: 10.7499/j.issn.1008-8830.2308076.
Abstract
The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is an essential component of the hypothalamic-pituitary growth hormone axis and plays a crucial role in childhood growth and development. Disruptions and abnormalities in the GH/IGF-1 signaling pathway and its pathways typically manifest as short stature in children. Children with short stature often undergo GH stimulation testing and IGF-1 level measurements to differentiate growth hormone deficiency (GHD) from other causes of growth delay. This article aims to analyze and elucidate the values of GH stimulation testing and IGF-1 measurement, providing reference for the diagnosis of GHD in children.
摘要
生长激素（GH）/胰岛素样生长因子1（IGF-1）轴是下丘脑-垂体生长激素轴的重要组成部分，在儿童生长发育中起关键作用。GH/IGF-1信号通路及其相关通路的破坏和异常通常表现为儿童身材矮小。身材矮小的儿童常进行GH刺激试验和IGF-1水平测量，以区分生长激素缺乏症（GHD）与其他生长迟缓原因。本文旨在分析和阐明GH刺激试验和IGF-1测量的价值，为儿童GHD的诊断提供参考。
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本文引用的文献
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Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study.精氨酸和可乐定刺激试验期间的生长激素反应：单中心研究中与患者生长学和代谢参数的相关性
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