无需生长激素刺激试验的生长激素缺乏症诊断
Diagnosis of GH Deficiency Without GH Stimulation Tests.
作者信息
Ibba Anastasia, Loche Sandro
机构信息
Struttura Semplice Dipartimentale (SSD) Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico "A. Cao", Azienda di Rilievo Nazionale ed Alta Specializzazione (ARNAS) G. Brotzu, Cagliari, Italy.
出版信息
Front Endocrinol (Lausanne). 2022 Feb 18;13:853290. doi: 10.3389/fendo.2022.853290. eCollection 2022.
Abstract
Growth hormone deficiency (GHD) is the most commonly affected pituitary hormone in childhood with a prevalence of 1 in 4000-10000 live births. GH stimulation testing (GHST) is commonly used in the diagnostic workup of GHD. However, GHD can be diagnosed in some clinical conditions without the need of GHST. The diagnosis of GHD in newborns does not require stimulation testing. Likewise infants/children with delayed growth and/or short stature associated with neuroradiological abnormalities and one or more additional pituitary hormone deficiencies may not need GHST. This review summarizes the current evidence on the diagnosis of GHD without stimulation tests.
摘要
生长激素缺乏症（GHD）是儿童期最常受影响的垂体激素缺乏症，在4000 - 10000例活产儿中的患病率为1/4000 - 1/10000。生长激素刺激试验（GHST）常用于GHD的诊断检查。然而，在某些临床情况下，无需进行GHST即可诊断GHD。新生儿GHD的诊断不需要刺激试验。同样，生长发育延迟和/或身材矮小且伴有神经放射学异常以及一种或多种其他垂体激素缺乏症的婴儿/儿童可能也不需要GHST。本综述总结了目前关于无需刺激试验诊断GHD的证据。
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